Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4245947..4246728 Replicon chromosome
Accession NZ_CP120395
Organism Salmonella enterica subsp. enterica serovar Typhi strain 1698-2017_CI

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag PVA70_RS21125 Protein ID WP_000626103.1
Coordinates 4245947..4246438 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag PVA70_RS21130 Protein ID WP_001110456.1
Coordinates 4246435..4246728 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA70_RS21105 (PVA70_21100) 4241714..4243078 - 1365 WP_000018529.1 SPI-7-type island replicative DNA helicase -
PVA70_RS21110 (PVA70_21105) 4243075..4244109 - 1035 WP_001195363.1 ParA family protein -
PVA70_RS21115 (PVA70_21115) 4244777..4244854 + 78 Protein_4140 porin family protein -
PVA70_RS21120 (PVA70_21120) 4244954..4245706 + 753 WP_001785756.1 non-specific acid phosphatase -
PVA70_RS21125 (PVA70_21125) 4245947..4246438 - 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
PVA70_RS21130 (PVA70_21130) 4246435..4246728 - 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
PVA70_RS21135 (PVA70_21135) 4247045..4247267 + 223 Protein_4144 hypothetical protein -
PVA70_RS21140 (PVA70_21140) 4247533..4248408 + 876 WP_000921674.1 AraC family transcriptional regulator -
PVA70_RS21145 (PVA70_21145) 4248405..4248692 + 288 WP_001269916.1 transcriptional regulator RtsB -
PVA70_RS21150 (PVA70_21150) 4248715..4248931 + 217 Protein_4147 hypothetical protein -
PVA70_RS21155 (PVA70_21155) 4248939..4249283 + 345 WP_100680417.1 Ig-like domain-containing protein -
PVA70_RS21160 (PVA70_21160) 4249570..4250475 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T275000 WP_000626103.1 NZ_CP120395:c4246438-4245947 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT275000 WP_001110456.1 NZ_CP120395:c4246728-4246435 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References