Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3903213..3903789 Replicon chromosome
Accession NZ_CP120395
Organism Salmonella enterica subsp. enterica serovar Typhi strain 1698-2017_CI

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PVA70_RS19320 Protein ID WP_001131963.1
Coordinates 3903502..3903789 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag PVA70_RS19315 Protein ID WP_000063142.1
Coordinates 3903213..3903515 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA70_RS19300 (PVA70_19300) 3899723..3901873 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
PVA70_RS19305 (PVA70_19305) 3901968..3902171 + 204 WP_000460616.1 YbdD/YjiX family protein -
PVA70_RS19310 (PVA70_19310) 3902182..3903138 + 957 WP_000187846.1 GTPase -
PVA70_RS19315 (PVA70_19315) 3903213..3903515 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
PVA70_RS19320 (PVA70_19320) 3903502..3903789 - 288 WP_001131963.1 BrnT family toxin Toxin
PVA70_RS19325 (PVA70_19325) 3904042..3904956 - 915 WP_000290515.1 restriction endonuclease -
PVA70_RS19330 (PVA70_19330) 3905154..3908663 + 3510 WP_001043493.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T274997 WP_001131963.1 NZ_CP120395:c3903789-3903502 [Salmonella enterica subsp. enterica serovar Typhi]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT274997 WP_000063142.1 NZ_CP120395:c3903515-3903213 [Salmonella enterica subsp. enterica serovar Typhi]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References