Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1404214..1404834 Replicon chromosome
Accession NZ_CP120395
Organism Salmonella enterica subsp. enterica serovar Typhi strain 1698-2017_CI

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PVA70_RS06875 Protein ID WP_001280991.1
Coordinates 1404214..1404432 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PVA70_RS06880 Protein ID WP_000344807.1
Coordinates 1404460..1404834 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA70_RS06835 (PVA70_06835) 1399437..1400006 + 570 WP_000779802.1 YbaY family lipoprotein -
PVA70_RS06840 (PVA70_06840) 1400039..1400428 - 390 WP_000961285.1 MGMT family protein -
PVA70_RS06850 (PVA70_06850) 1400659..1402209 - 1551 WP_000213129.1 EAL domain-containing protein -
PVA70_RS06855 (PVA70_06855) 1402434..1402694 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PVA70_RS06860 (PVA70_06860) 1402700..1402840 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PVA70_RS06865 (PVA70_06865) 1402896..1403366 - 471 WP_000136183.1 YlaC family protein -
PVA70_RS06870 (PVA70_06870) 1403484..1404035 - 552 WP_001278793.1 maltose O-acetyltransferase -
PVA70_RS06875 (PVA70_06875) 1404214..1404432 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PVA70_RS06880 (PVA70_06880) 1404460..1404834 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PVA70_RS06885 (PVA70_06885) 1405330..1408479 - 3150 WP_001132507.1 efflux RND transporter permease AcrB -
PVA70_RS06890 (PVA70_06890) 1408502..1409695 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T274992 WP_001280991.1 NZ_CP120395:c1404432-1404214 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT274992 WP_000344807.1 NZ_CP120395:c1404834-1404460 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References