Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4951860..4952357 Replicon chromosome
Accession NC_017646
Organism Escherichia coli O7:K1 str. CE10

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag CE10_RS24970 Protein ID WP_001173343.1
Coordinates 4952184..4952357 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag CE10_RS24965 Protein ID WP_000398619.1
Coordinates 4951860..4952156 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CE10_RS24945 4948589..4949308 - 720 WP_000611288.1 two-component system response regulator DcuR -
CE10_RS24950 4949305..4950936 - 1632 WP_001216448.1 sensor histidine kinase -
CE10_RS24955 4951117..4951347 + 231 WP_000371713.1 (4Fe-4S)-binding protein -
CE10_RS24960 4951359..4951631 + 273 WP_000405647.1 N-acetyltransferase -
CE10_RS24965 4951860..4952156 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
CE10_RS24970 4952184..4952357 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
CE10_RS24975 4952476..4953993 - 1518 WP_000003800.1 lysine--tRNA ligase -
CE10_RS24980 4954230..4955682 - 1453 Protein_4711 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T27499 WP_001173343.1 NC_017646:4952184-4952357 [Escherichia coli O7:K1 str. CE10]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T27499 NC_017646:4952184-4952357 [Escherichia coli O7:K1 str. CE10]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGCGCATTCCTGGTCGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT27499 WP_000398619.1 NC_017646:4951860-4952156 [Escherichia coli O7:K1 str. CE10]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT27499 NC_017646:4951860-4952156 [Escherichia coli O7:K1 str. CE10]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References