Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4636160..4636776 Replicon chromosome
Accession NZ_CP120394
Organism Salmonella enterica subsp. enterica serovar Typhi strain 2027-2019_CI

Toxin (Protein)


Gene name vapC Uniprot ID Q8Z2U3
Locus tag PVA73_RS22905 Protein ID WP_000238494.1
Coordinates 4636160..4636534 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E9YHE9
Locus tag PVA73_RS22910 Protein ID WP_001523745.1
Coordinates 4636534..4636776 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA73_RS22890 (PVA73_22885) 4633662..4634564 + 903 WP_000331359.1 formate dehydrogenase subunit beta -
PVA73_RS22895 (PVA73_22890) 4634561..4635196 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PVA73_RS22900 (PVA73_22895) 4635193..4636122 + 930 WP_000027727.1 formate dehydrogenase accessory protein FdhE -
PVA73_RS22905 (PVA73_22900) 4636160..4636534 - 375 WP_000238494.1 type II toxin-antitoxin system VapC family toxin Toxin
PVA73_RS22910 (PVA73_22905) 4636534..4636776 - 243 WP_001523745.1 CopG family transcriptional regulator Antitoxin
PVA73_RS22915 (PVA73_22910) 4636981..4637910 + 930 WP_001162859.1 alpha/beta hydrolase -
PVA73_RS22920 (PVA73_22915) 4637996..4638307 + 312 WP_000558160.1 type II toxin-antitoxin system HigB family toxin -
PVA73_RS22925 (PVA73_22920) 4638304..4638750 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
PVA73_RS22930 (PVA73_22925) 4638765..4639706 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PVA73_RS22935 (PVA73_22930) 4639751..4640188 - 438 WP_000560975.1 D-aminoacyl-tRNA deacylase -
PVA73_RS22940 (PVA73_22935) 4640185..4641057 - 873 WP_000921423.1 virulence factor BrkB family protein -
PVA73_RS22945 (PVA73_22940) 4641051..4641650 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13908.18 Da        Isoelectric Point: 7.3567

>T274986 WP_000238494.1 NZ_CP120394:c4636534-4636160 [Salmonella enterica subsp. enterica serovar Typhi]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 4.4463

>AT274986 WP_001523745.1 NZ_CP120394:c4636776-4636534 [Salmonella enterica subsp. enterica serovar Typhi]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CND8

Antitoxin

Source ID Structure

References