Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4248271..4249052 Replicon chromosome
Accession NZ_CP120394
Organism Salmonella enterica subsp. enterica serovar Typhi strain 2027-2019_CI

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag PVA73_RS21080 Protein ID WP_000626103.1
Coordinates 4248271..4248762 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag PVA73_RS21085 Protein ID WP_001110456.1
Coordinates 4248759..4249052 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA73_RS21060 (PVA73_21055) 4244038..4245402 - 1365 WP_000018529.1 SPI-7-type island replicative DNA helicase -
PVA73_RS21065 (PVA73_21060) 4245399..4246349 - 951 WP_000068773.1 ParA family protein -
PVA73_RS21070 (PVA73_21070) 4247101..4247178 + 78 Protein_4129 porin family protein -
PVA73_RS21075 (PVA73_21075) 4247278..4248030 + 753 WP_001785756.1 non-specific acid phosphatase -
PVA73_RS21080 (PVA73_21080) 4248271..4248762 - 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
PVA73_RS21085 (PVA73_21085) 4248759..4249052 - 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
PVA73_RS21090 (PVA73_21090) 4249369..4249591 + 223 Protein_4133 hypothetical protein -
PVA73_RS21095 (PVA73_21095) 4249857..4250732 + 876 WP_000921674.1 AraC family transcriptional regulator -
PVA73_RS21100 (PVA73_21100) 4250729..4251016 + 288 WP_001269916.1 transcriptional regulator RtsB -
PVA73_RS21105 (PVA73_21105) 4251039..4251255 + 217 Protein_4136 hypothetical protein -
PVA73_RS21110 (PVA73_21110) 4251263..4251607 + 345 WP_100680417.1 Ig-like domain-containing protein -
PVA73_RS21115 (PVA73_21115) 4251894..4252799 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T274985 WP_000626103.1 NZ_CP120394:c4248762-4248271 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT274985 WP_001110456.1 NZ_CP120394:c4249052-4248759 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References