Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1388705..1389325 Replicon chromosome
Accession NZ_CP120394
Organism Salmonella enterica subsp. enterica serovar Typhi strain 2027-2019_CI

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PVA73_RS06775 Protein ID WP_001280991.1
Coordinates 1388705..1388923 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PVA73_RS06780 Protein ID WP_000344807.1
Coordinates 1388951..1389325 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA73_RS06735 (PVA73_06735) 1383928..1384497 + 570 WP_000779802.1 YbaY family lipoprotein -
PVA73_RS06740 (PVA73_06740) 1384530..1384919 - 390 WP_000961285.1 MGMT family protein -
PVA73_RS06750 (PVA73_06750) 1385150..1386700 - 1551 WP_000213129.1 EAL domain-containing protein -
PVA73_RS06755 (PVA73_06755) 1386925..1387185 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PVA73_RS06760 (PVA73_06760) 1387191..1387331 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PVA73_RS06765 (PVA73_06765) 1387387..1387857 - 471 WP_000136183.1 YlaC family protein -
PVA73_RS06770 (PVA73_06770) 1387975..1388526 - 552 WP_001278793.1 maltose O-acetyltransferase -
PVA73_RS06775 (PVA73_06775) 1388705..1388923 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PVA73_RS06780 (PVA73_06780) 1388951..1389325 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PVA73_RS06785 (PVA73_06785) 1389821..1392970 - 3150 WP_001132507.1 efflux RND transporter permease AcrB -
PVA73_RS06790 (PVA73_06790) 1392993..1394186 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T274977 WP_001280991.1 NZ_CP120394:c1388923-1388705 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT274977 WP_000344807.1 NZ_CP120394:c1389325-1388951 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References