Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 974047..974861 | Replicon | chromosome |
| Accession | NZ_CP120394 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain 2027-2019_CI | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | Q57KM2 |
| Locus tag | PVA73_RS04745 | Protein ID | WP_000971655.1 |
| Coordinates | 974047..974574 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | PVA73_RS04750 | Protein ID | WP_000855694.1 |
| Coordinates | 974571..974861 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PVA73_RS04725 (PVA73_04725) | 969255..971822 | - | 2568 | WP_001005807.1 | DNA mismatch repair protein MutS | - |
| PVA73_RS04730 (PVA73_04730) | 971980..972500 | + | 521 | Protein_927 | cytoplasmic protein | - |
| PVA73_RS04735 (PVA73_04735) | 972670..973326 | - | 657 | WP_000420463.1 | protein-serine/threonine phosphatase | - |
| PVA73_RS04740 (PVA73_04740) | 973553..973974 | + | 422 | Protein_929 | IS5/IS1182 family transposase | - |
| PVA73_RS04745 (PVA73_04745) | 974047..974574 | - | 528 | WP_000971655.1 | GNAT family N-acetyltransferase | Toxin |
| PVA73_RS04750 (PVA73_04750) | 974571..974861 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| PVA73_RS04755 (PVA73_04755) | 975131..975331 | - | 201 | Protein_932 | transposase | - |
| PVA73_RS04760 (PVA73_04760) | 975735..976178 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| PVA73_RS04765 (PVA73_04765) | 976634..977284 | + | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
| PVA73_RS04770 (PVA73_04770) | 977281..978969 | + | 1689 | WP_000848103.1 | type III secretion system outer membrane ring protein InvG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 973828..982597 | 8769 | |
| - | flank | IS/Tn | - | - | 973828..973974 | 146 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19069.91 Da Isoelectric Point: 9.6420
>T274976 WP_000971655.1 NZ_CP120394:c974574-974047 [Salmonella enterica subsp. enterica serovar Typhi]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT274976 WP_000855694.1 NZ_CP120394:c974861-974571 [Salmonella enterica subsp. enterica serovar Typhi]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 6G96 | |
| PDB | 7AK9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |