Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 820510..821135 Replicon chromosome
Accession NZ_CP120394
Organism Salmonella enterica subsp. enterica serovar Typhi strain 2027-2019_CI

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PVA73_RS04030 Protein ID WP_000911334.1
Coordinates 820737..821135 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PVA73_RS04025 Protein ID WP_000557549.1
Coordinates 820510..820737 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA73_RS03995 (PVA73_03995) 815681..816400 + 720 WP_000082599.1 Rha family transcriptional regulator -
PVA73_RS04000 (PVA73_04000) 816404..816607 + 204 WP_000184036.1 hypothetical protein -
PVA73_RS04005 (PVA73_04005) 816690..817145 + 456 WP_223229661.1 hypothetical protein -
PVA73_RS04010 (PVA73_04010) 817247..818368 + 1122 WP_000028980.1 hypothetical protein -
PVA73_RS04015 (PVA73_04015) 819001..819807 - 807 WP_077905073.1 DUF1460 domain-containing protein -
PVA73_RS04020 (PVA73_04020) 820082..820333 - 252 WP_001540858.1 hypothetical protein -
PVA73_RS04025 (PVA73_04025) 820510..820737 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PVA73_RS04030 (PVA73_04030) 820737..821135 + 399 WP_000911334.1 tRNA(fMet)-specific endonuclease VapC Toxin
PVA73_RS04035 (PVA73_04035) 821942..822478 + 537 WP_001038500.1 STM3031 family outer membrane protein -
PVA73_RS04040 (PVA73_04040) 822525..823157 + 633 WP_000835268.1 YfdX family protein -
PVA73_RS04045 (PVA73_04045) 823876..824457 + 582 WP_001244646.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 813429..829580 16151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.7785

>T274975 WP_000911334.1 NZ_CP120394:820737-821135 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT274975 WP_000557549.1 NZ_CP120394:820510-820737 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References