Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4675982..4676598 Replicon chromosome
Accession NZ_CP120393
Organism Salmonella enterica subsp. enterica serovar Typhi strain 1698-2017_CO_06

Toxin (Protein)


Gene name vapC Uniprot ID Q8Z2U3
Locus tag PVA83_RS23050 Protein ID WP_000238494.1
Coordinates 4675982..4676356 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E9YHE9
Locus tag PVA83_RS23055 Protein ID WP_001523745.1
Coordinates 4676356..4676598 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA83_RS23035 (PVA83_23035) 4673484..4674386 + 903 WP_000331359.1 formate dehydrogenase subunit beta -
PVA83_RS23040 (PVA83_23040) 4674383..4675018 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PVA83_RS23045 (PVA83_23045) 4675015..4675944 + 930 WP_000027727.1 formate dehydrogenase accessory protein FdhE -
PVA83_RS23050 (PVA83_23050) 4675982..4676356 - 375 WP_000238494.1 type II toxin-antitoxin system VapC family toxin Toxin
PVA83_RS23055 (PVA83_23055) 4676356..4676598 - 243 WP_001523745.1 CopG family transcriptional regulator Antitoxin
PVA83_RS23060 (PVA83_23060) 4676803..4677732 + 930 WP_001162859.1 alpha/beta hydrolase -
PVA83_RS23065 (PVA83_23065) 4677818..4678129 + 312 WP_000558160.1 type II toxin-antitoxin system HigB family toxin -
PVA83_RS23070 (PVA83_23070) 4678126..4678572 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
PVA83_RS23075 (PVA83_23075) 4678587..4679528 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PVA83_RS23080 (PVA83_23080) 4679573..4680010 - 438 WP_000560975.1 D-aminoacyl-tRNA deacylase -
PVA83_RS23085 (PVA83_23085) 4680007..4680879 - 873 WP_000921423.1 virulence factor BrkB family protein -
PVA83_RS23090 (PVA83_23090) 4680873..4681472 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13908.18 Da        Isoelectric Point: 7.3567

>T274971 WP_000238494.1 NZ_CP120393:c4676356-4675982 [Salmonella enterica subsp. enterica serovar Typhi]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 4.4463

>AT274971 WP_001523745.1 NZ_CP120393:c4676598-4676356 [Salmonella enterica subsp. enterica serovar Typhi]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CND8

Antitoxin

Source ID Structure

References