Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4245839..4246620 Replicon chromosome
Accession NZ_CP120393
Organism Salmonella enterica subsp. enterica serovar Typhi strain 1698-2017_CO_06

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag PVA83_RS21025 Protein ID WP_000626103.1
Coordinates 4245839..4246330 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag PVA83_RS21030 Protein ID WP_001110456.1
Coordinates 4246327..4246620 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA83_RS21005 (PVA83_21000) 4241606..4242970 - 1365 WP_000018529.1 SPI-7-type island replicative DNA helicase -
PVA83_RS21010 (PVA83_21005) 4242967..4244001 - 1035 WP_001195363.1 ParA family protein -
PVA83_RS21015 (PVA83_21015) 4244669..4244746 + 78 Protein_4120 porin family protein -
PVA83_RS21020 (PVA83_21020) 4244846..4245598 + 753 WP_001785756.1 non-specific acid phosphatase -
PVA83_RS21025 (PVA83_21025) 4245839..4246330 - 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
PVA83_RS21030 (PVA83_21030) 4246327..4246620 - 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
PVA83_RS21035 (PVA83_21035) 4246937..4247159 + 223 Protein_4124 hypothetical protein -
PVA83_RS21040 (PVA83_21040) 4247425..4248300 + 876 WP_000921674.1 AraC family transcriptional regulator -
PVA83_RS21045 (PVA83_21045) 4248297..4248584 + 288 WP_001269916.1 transcriptional regulator RtsB -
PVA83_RS21050 (PVA83_21050) 4248607..4248823 + 217 Protein_4127 hypothetical protein -
PVA83_RS21055 (PVA83_21055) 4248831..4249175 + 345 WP_100680417.1 Ig-like domain-containing protein -
PVA83_RS21060 (PVA83_21060) 4249462..4250367 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T274970 WP_000626103.1 NZ_CP120393:c4246330-4245839 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT274970 WP_001110456.1 NZ_CP120393:c4246620-4246327 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References