Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3903105..3903681 Replicon chromosome
Accession NZ_CP120393
Organism Salmonella enterica subsp. enterica serovar Typhi strain 1698-2017_CO_06

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PVA83_RS19225 Protein ID WP_001131963.1
Coordinates 3903394..3903681 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag PVA83_RS19220 Protein ID WP_000063142.1
Coordinates 3903105..3903407 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA83_RS19205 (PVA83_19205) 3899615..3901765 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
PVA83_RS19210 (PVA83_19210) 3901860..3902063 + 204 WP_000460616.1 YbdD/YjiX family protein -
PVA83_RS19215 (PVA83_19215) 3902074..3903030 + 957 WP_000187846.1 GTPase -
PVA83_RS19220 (PVA83_19220) 3903105..3903407 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
PVA83_RS19225 (PVA83_19225) 3903394..3903681 - 288 WP_001131963.1 BrnT family toxin Toxin
PVA83_RS19230 (PVA83_19230) 3903934..3904848 - 915 WP_000290515.1 restriction endonuclease -
PVA83_RS19235 (PVA83_19235) 3905046..3908555 + 3510 WP_001043493.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T274967 WP_001131963.1 NZ_CP120393:c3903681-3903394 [Salmonella enterica subsp. enterica serovar Typhi]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT274967 WP_000063142.1 NZ_CP120393:c3903407-3903105 [Salmonella enterica subsp. enterica serovar Typhi]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References