Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4248140..4248921 Replicon chromosome
Accession NZ_CP120392
Organism Salmonella enterica subsp. enterica serovar Typhi strain 2027-2019_CO_04_Copr1

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag PVA84_RS21090 Protein ID WP_000626103.1
Coordinates 4248140..4248631 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag PVA84_RS21095 Protein ID WP_001110456.1
Coordinates 4248628..4248921 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA84_RS21070 (PVA84_21065) 4243907..4245271 - 1365 WP_000018529.1 SPI-7-type island replicative DNA helicase -
PVA84_RS21075 (PVA84_21070) 4245268..4246302 - 1035 WP_001195363.1 ParA family protein -
PVA84_RS21080 (PVA84_21080) 4246970..4247047 + 78 Protein_4131 porin family protein -
PVA84_RS21085 (PVA84_21085) 4247147..4247899 + 753 WP_001785756.1 non-specific acid phosphatase -
PVA84_RS21090 (PVA84_21090) 4248140..4248631 - 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
PVA84_RS21095 (PVA84_21095) 4248628..4248921 - 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
PVA84_RS21100 (PVA84_21100) 4249238..4249460 + 223 Protein_4135 hypothetical protein -
PVA84_RS21105 (PVA84_21105) 4249726..4250601 + 876 WP_000921674.1 AraC family transcriptional regulator -
PVA84_RS21110 (PVA84_21110) 4250598..4250885 + 288 WP_001269916.1 transcriptional regulator RtsB -
PVA84_RS21115 (PVA84_21115) 4250908..4251124 + 217 Protein_4138 hypothetical protein -
PVA84_RS21120 (PVA84_21120) 4251132..4251476 + 345 WP_100680417.1 Ig-like domain-containing protein -
PVA84_RS21125 (PVA84_21125) 4251763..4252668 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T274955 WP_000626103.1 NZ_CP120392:c4248631-4248140 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT274955 WP_001110456.1 NZ_CP120392:c4248921-4248628 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References