Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4008588..4009104 Replicon chromosome
Accession NZ_CP120392
Organism Salmonella enterica subsp. enterica serovar Typhi strain 2027-2019_CO_04_Copr1

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag PVA84_RS19770 Protein ID WP_000220578.1
Coordinates 4008588..4008872 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PVA84_RS19775 Protein ID WP_000212724.1
Coordinates 4008862..4009104 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA84_RS19755 (PVA84_19750) 4003800..4005452 + 1653 WP_000155051.1 alpha,alpha-phosphotrehalase -
PVA84_RS19760 (PVA84_19755) 4005861..4007999 + 2139 WP_000187820.1 anaerobic ribonucleoside-triphosphate reductase -
PVA84_RS19765 (PVA84_19760) 4008120..4008584 + 465 WP_001268860.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PVA84_RS19770 (PVA84_19765) 4008588..4008872 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PVA84_RS19775 (PVA84_19770) 4008862..4009104 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PVA84_RS19780 (PVA84_19775) 4009182..4011095 - 1914 WP_001212152.1 BglG family transcription antiterminator -
PVA84_RS19785 (PVA84_19780) 4011112..4011852 - 741 WP_000779260.1 KDGP aldolase family protein -
PVA84_RS19790 (PVA84_19785) 4011849..4012967 - 1119 WP_001139189.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PVA84_RS19795 (PVA84_19790) 4012951..4014084 - 1134 WP_000459938.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T274953 WP_000220578.1 NZ_CP120392:c4008872-4008588 [Salmonella enterica subsp. enterica serovar Typhi]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT274953 WP_000212724.1 NZ_CP120392:c4009104-4008862 [Salmonella enterica subsp. enterica serovar Typhi]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References