Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | shpAB/BrnT-BrnA |
Location | 3906034..3906610 | Replicon | chromosome |
Accession | NZ_CP120392 | ||
Organism | Salmonella enterica subsp. enterica serovar Typhi strain 2027-2019_CO_04_Copr1 |
Toxin (Protein)
Gene name | shpA | Uniprot ID | M7RG88 |
Locus tag | PVA84_RS19295 | Protein ID | WP_001131963.1 |
Coordinates | 3906323..3906610 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | shpB | Uniprot ID | B5R9R5 |
Locus tag | PVA84_RS19290 | Protein ID | WP_000063142.1 |
Coordinates | 3906034..3906336 (-) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PVA84_RS19275 (PVA84_19275) | 3902544..3904694 | + | 2151 | WP_000379928.1 | pyruvate/proton symporter BtsT | - |
PVA84_RS19280 (PVA84_19280) | 3904789..3904992 | + | 204 | WP_000460616.1 | YbdD/YjiX family protein | - |
PVA84_RS19285 (PVA84_19285) | 3905003..3905959 | + | 957 | WP_000187846.1 | GTPase | - |
PVA84_RS19290 (PVA84_19290) | 3906034..3906336 | - | 303 | WP_000063142.1 | BrnA antitoxin family protein | Antitoxin |
PVA84_RS19295 (PVA84_19295) | 3906323..3906610 | - | 288 | WP_001131963.1 | BrnT family toxin | Toxin |
PVA84_RS19300 (PVA84_19300) | 3906863..3907777 | - | 915 | WP_000290515.1 | restriction endonuclease | - |
PVA84_RS19305 (PVA84_19305) | 3907975..3911484 | + | 3510 | WP_001043493.1 | type I restriction-modification system endonuclease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11294.80 Da Isoelectric Point: 9.5894
>T274952 WP_001131963.1 NZ_CP120392:c3906610-3906323 [Salmonella enterica subsp. enterica serovar Typhi]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG
Download Length: 288 bp
Antitoxin
Download Length: 101 a.a. Molecular weight: 11373.96 Da Isoelectric Point: 10.1293
>AT274952 WP_000063142.1 NZ_CP120392:c3906336-3906034 [Salmonella enterica subsp. enterica serovar Typhi]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK
Download Length: 303 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 7VD7 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 7VD7 | |
AlphaFold DB | A0A4D6PB01 |