Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3326236..3326856 Replicon chromosome
Accession NZ_CP120392
Organism Salmonella enterica subsp. enterica serovar Typhi strain 2027-2019_CO_04_Copr1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PVA84_RS16575 Protein ID WP_001280991.1
Coordinates 3326638..3326856 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PVA84_RS16570 Protein ID WP_000344807.1
Coordinates 3326236..3326610 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA84_RS16560 (PVA84_16560) 3321375..3322568 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PVA84_RS16565 (PVA84_16565) 3322591..3325740 + 3150 WP_001132507.1 efflux RND transporter permease AcrB -
PVA84_RS16570 (PVA84_16570) 3326236..3326610 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PVA84_RS16575 (PVA84_16575) 3326638..3326856 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PVA84_RS16580 (PVA84_16580) 3327035..3327586 + 552 WP_001278793.1 maltose O-acetyltransferase -
PVA84_RS16585 (PVA84_16585) 3327704..3328174 + 471 WP_000136183.1 YlaC family protein -
PVA84_RS16590 (PVA84_16590) 3328230..3328370 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PVA84_RS16595 (PVA84_16595) 3328376..3328636 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PVA84_RS16600 (PVA84_16600) 3328861..3330411 + 1551 WP_000213129.1 EAL domain-containing protein -
PVA84_RS16610 (PVA84_16610) 3330642..3331031 + 390 WP_000961285.1 MGMT family protein -
PVA84_RS16615 (PVA84_16615) 3331064..3331633 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T274951 WP_001280991.1 NZ_CP120392:3326638-3326856 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT274951 WP_000344807.1 NZ_CP120392:3326236-3326610 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References