Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 974040..974854 | Replicon | chromosome |
| Accession | NZ_CP120392 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain 2027-2019_CO_04_Copr1 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | Q57KM2 |
| Locus tag | PVA84_RS04750 | Protein ID | WP_000971655.1 |
| Coordinates | 974040..974567 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | PVA84_RS04755 | Protein ID | WP_000855694.1 |
| Coordinates | 974564..974854 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PVA84_RS04730 (PVA84_04730) | 969248..971815 | - | 2568 | WP_001005807.1 | DNA mismatch repair protein MutS | - |
| PVA84_RS04735 (PVA84_04735) | 971973..972493 | + | 521 | Protein_928 | cytoplasmic protein | - |
| PVA84_RS04740 (PVA84_04740) | 972663..973319 | - | 657 | WP_000420463.1 | protein-serine/threonine phosphatase | - |
| PVA84_RS04745 (PVA84_04745) | 973546..973967 | + | 422 | Protein_930 | IS5/IS1182 family transposase | - |
| PVA84_RS04750 (PVA84_04750) | 974040..974567 | - | 528 | WP_000971655.1 | GNAT family N-acetyltransferase | Toxin |
| PVA84_RS04755 (PVA84_04755) | 974564..974854 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| PVA84_RS04760 (PVA84_04760) | 975124..975324 | - | 201 | Protein_933 | transposase | - |
| PVA84_RS04765 (PVA84_04765) | 975728..976171 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| PVA84_RS04770 (PVA84_04770) | 976627..977277 | + | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
| PVA84_RS04775 (PVA84_04775) | 977274..978962 | + | 1689 | WP_000848103.1 | type III secretion system outer membrane ring protein InvG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 973821..982590 | 8769 | |
| - | flank | IS/Tn | - | - | 973821..973967 | 146 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19069.91 Da Isoelectric Point: 9.6420
>T274946 WP_000971655.1 NZ_CP120392:c974567-974040 [Salmonella enterica subsp. enterica serovar Typhi]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT274946 WP_000855694.1 NZ_CP120392:c974854-974564 [Salmonella enterica subsp. enterica serovar Typhi]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 6G96 | |
| PDB | 7AK9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |