Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 820509..821134 Replicon chromosome
Accession NZ_CP120392
Organism Salmonella enterica subsp. enterica serovar Typhi strain 2027-2019_CO_04_Copr1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PVA84_RS04030 Protein ID WP_000911334.1
Coordinates 820736..821134 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PVA84_RS04025 Protein ID WP_000557549.1
Coordinates 820509..820736 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA84_RS03995 (PVA84_03995) 815680..816399 + 720 WP_000082599.1 Rha family transcriptional regulator -
PVA84_RS04000 (PVA84_04000) 816403..816606 + 204 WP_000184036.1 hypothetical protein -
PVA84_RS04005 (PVA84_04005) 816689..817144 + 456 WP_223229661.1 hypothetical protein -
PVA84_RS04010 (PVA84_04010) 817246..818367 + 1122 WP_000028980.1 hypothetical protein -
PVA84_RS04015 (PVA84_04015) 819000..819806 - 807 WP_077905073.1 DUF1460 domain-containing protein -
PVA84_RS04020 (PVA84_04020) 820081..820332 - 252 WP_001540858.1 hypothetical protein -
PVA84_RS04025 (PVA84_04025) 820509..820736 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PVA84_RS04030 (PVA84_04030) 820736..821134 + 399 WP_000911334.1 tRNA(fMet)-specific endonuclease VapC Toxin
PVA84_RS04035 (PVA84_04035) 821941..822477 + 537 WP_001038500.1 STM3031 family outer membrane protein -
PVA84_RS04040 (PVA84_04040) 822524..823156 + 633 WP_000835268.1 YfdX family protein -
PVA84_RS04045 (PVA84_04045) 823875..824456 + 582 WP_001244646.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 813428..829579 16151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.7785

>T274945 WP_000911334.1 NZ_CP120392:820736-821134 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT274945 WP_000557549.1 NZ_CP120392:820509-820736 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References