Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5860417..5861550 Replicon chromosome
Accession NZ_CP120376
Organism Pseudomonas nitroreducens strain L4

Toxin (Protein)


Gene name - Uniprot ID A0A1B8SZD5
Locus tag P3T65_RS26860 Protein ID WP_065085981.1
Coordinates 5860417..5861181 (-) Length 255 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1B8V7T7
Locus tag P3T65_RS26865 Protein ID WP_024763405.1
Coordinates 5861182..5861550 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3T65_RS26845 (P3T65_26845) 5855826..5856716 + 891 WP_065085978.1 metal-dependent hydrolase -
P3T65_RS26850 (P3T65_26850) 5856805..5858151 + 1347 WP_084357525.1 FAD-binding oxidoreductase -
P3T65_RS26855 (P3T65_26855) 5858195..5859559 - 1365 WP_277369451.1 DNA recombination protein RmuC -
P3T65_RS26860 (P3T65_26860) 5860417..5861181 - 765 WP_065085981.1 RES family NAD+ phosphorylase Toxin
P3T65_RS26865 (P3T65_26865) 5861182..5861550 - 369 WP_024763405.1 DUF2384 domain-containing protein Antitoxin
P3T65_RS26870 (P3T65_26870) 5861820..5862311 + 492 WP_065085982.1 RcnB family protein -
P3T65_RS26875 (P3T65_26875) 5862318..5862749 - 432 WP_024763403.1 hypothetical protein -
P3T65_RS26880 (P3T65_26880) 5862874..5863356 + 483 WP_065085983.1 GreA/GreB family elongation factor -
P3T65_RS26885 (P3T65_26885) 5863490..5863837 + 348 WP_017522075.1 carboxymuconolactone decarboxylase family protein -
P3T65_RS26890 (P3T65_26890) 5863937..5864305 + 369 WP_024763401.1 hypothetical protein -
P3T65_RS26895 (P3T65_26895) 5864540..5864881 - 342 WP_277368790.1 type II toxin-antitoxin system RelE/ParE family toxin -
P3T65_RS26900 (P3T65_26900) 5864888..5865136 - 249 WP_277368791.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
P3T65_RS26905 (P3T65_26905) 5865237..5866511 - 1275 WP_277368792.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(68-210)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(10-67)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 28877.06 Da        Isoelectric Point: 8.4428

>T274940 WP_065085981.1 NZ_CP120376:c5861181-5860417 [Pseudomonas nitroreducens]
MSFEAGARLWAKYEDSVVAPIRGRLVRLVESQGQVATLQLVDTLEEQALLEELLETSKPRMPSSAEPLHYLLKTPFRYPP
LRWGSRFGRRHEPSLFYGALKLETAMAESAFYRFVLWEGMATPPPSGRILSEHASFEARFQVQKGVRLHLPPFREHAALL
DPQDYSVTQGMGSAMRDAGVEAFEYRSARCPQGGINVALFVPSAFTEKRPRNLMPWLCETTSEYVAFKHAQVPDSPRIYR
REQYLVDGRLPHPA

Download         Length: 765 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13515.77 Da        Isoelectric Point: 10.1440

>AT274940 WP_024763405.1 NZ_CP120376:c5861550-5861182 [Pseudomonas nitroreducens]
MSALLKENPAADTVLAKAVLTAREHLAMTQQELAAIVGVDRSAVSRWKQNGLRVDSKTGELALLLVRIYRALFALFGGNH
EDMRHFLRTENRHLGGVPLQLMERVQGLVAVVEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B8SZD5

Antitoxin

Source ID Structure
AlphaFold DB A0A1B8V7T7

References