Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2638154..2638620 Replicon chromosome
Accession NZ_CP120376
Organism Pseudomonas nitroreducens strain L4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag P3T65_RS12245 Protein ID WP_277369418.1
Coordinates 2638435..2638620 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1B8TB76
Locus tag P3T65_RS12240 Protein ID WP_037011255.1
Coordinates 2638154..2638450 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3T65_RS12215 (P3T65_12215) 2633488..2634126 - 639 WP_038803252.1 membrane protein -
P3T65_RS12220 (P3T65_12220) 2634263..2635573 - 1311 WP_277369314.1 HAMP domain-containing sensor histidine kinase -
P3T65_RS12225 (P3T65_12225) 2635570..2636310 - 741 WP_024767564.1 response regulator -
P3T65_RS12230 (P3T65_12230) 2636536..2636808 + 273 WP_024767565.1 DUF2790 domain-containing protein -
P3T65_RS12235 (P3T65_12235) 2636902..2638122 + 1221 WP_277369315.1 cytochrome c biogenesis protein DipZ -
P3T65_RS12240 (P3T65_12240) 2638154..2638450 - 297 WP_037011255.1 putative addiction module antidote protein Antitoxin
P3T65_RS12245 (P3T65_12245) 2638435..2638620 - 186 WP_277369418.1 hypothetical protein Toxin
P3T65_RS12250 (P3T65_12250) 2638859..2640706 - 1848 WP_084358319.1 diguanylate cyclase -
P3T65_RS12260 (P3T65_12260) 2641048..2641941 - 894 WP_065085020.1 alpha/beta hydrolase -
P3T65_RS12265 (P3T65_12265) 2642444..2643277 + 834 WP_024767718.1 transporter substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-54)

Antitoxin

Uncharacterized protein HI1420

(7-93)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6758.88 Da        Isoelectric Point: 8.5213

>T274939 WP_277369418.1 NZ_CP120376:c2638620-2638435 [Pseudomonas nitroreducens]
IRSMGIGVSEIRLDVGPGYCVYFRRRGDVPILLLCGGEKTSQQRDIKLAQQLAGAIEWPLN

Download         Length: 186 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10565.04 Da        Isoelectric Point: 4.6263

>AT274939 WP_037011255.1 NZ_CP120376:c2638450-2638154 [Pseudomonas nitroreducens]
MAIELSDFDTSHHLDNEEVIAEYLSQVLSDGDTDELLLAIGNIAKARGMTKIANDSGLGRESLYKVFAPGAKPRFETVMK
VMRALGVELQAIPASSGK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1B8TB76

References