Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1370519..1371024 Replicon chromosome
Accession NZ_CP120376
Organism Pseudomonas nitroreducens strain L4

Toxin (Protein)


Gene name parE Uniprot ID A0A1B8TFU7
Locus tag P3T65_RS06295 Protein ID WP_024763697.1
Coordinates 1370519..1370800 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1B8V0Q7
Locus tag P3T65_RS06300 Protein ID WP_024763698.1
Coordinates 1370797..1371024 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3T65_RS06270 (P3T65_06270) 1366420..1367370 + 951 WP_277369135.1 alpha/beta hydrolase -
P3T65_RS06275 (P3T65_06275) 1367444..1368472 + 1029 WP_231387660.1 AraC family transcriptional regulator -
P3T65_RS06280 (P3T65_06280) 1368474..1368929 - 456 WP_084358453.1 GNAT family N-acetyltransferase -
P3T65_RS06285 (P3T65_06285) 1368973..1369890 - 918 WP_024763695.1 LysR family transcriptional regulator -
P3T65_RS06290 (P3T65_06290) 1369988..1370275 + 288 WP_024763696.1 DUF2218 domain-containing protein -
P3T65_RS06295 (P3T65_06295) 1370519..1370800 - 282 WP_024763697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P3T65_RS06300 (P3T65_06300) 1370797..1371024 - 228 WP_024763698.1 CopG family ribbon-helix-helix protein Antitoxin
P3T65_RS06305 (P3T65_06305) 1371265..1372650 + 1386 WP_038803461.1 sodium:solute symporter -
P3T65_RS06310 (P3T65_06310) 1372678..1373634 + 957 WP_024763699.1 agmatinase -
P3T65_RS06315 (P3T65_06315) 1373710..1374636 + 927 WP_024763700.1 LysR family transcriptional regulator -
P3T65_RS06320 (P3T65_06320) 1374633..1375346 + 714 WP_024763701.1 phytanoyl-CoA dioxygenase family protein -
P3T65_RS06325 (P3T65_06325) 1375362..1375763 + 402 WP_024763702.1 GFA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10323.76 Da        Isoelectric Point: 5.6558

>T274937 WP_024763697.1 NZ_CP120376:c1370800-1370519 [Pseudomonas nitroreducens]
MSLQWTHKAAADLDAIYDHYVVLIGPEKALRAIQDIVEQVSPLANLDLSSSGVPSEVPGVRELSVERWPYQAAFRVKGRS
VQILRIDRVDNPG

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8245.19 Da        Isoelectric Point: 5.9478

>AT274937 WP_024763698.1 NZ_CP120376:c1371024-1370797 [Pseudomonas nitroreducens]
VTTVVSFRADDSLVAALDQLARATHRDRPYHLRQALAQYLERQSWHVAAIDEGVADADAGHLLEHAAIEGKWGLA

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B8TFU7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B8V0Q7

References