Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 585044..585720 Replicon plasmid unnamed
Accession NZ_CP120372
Organism Sinorhizobium numidicum strain LMG 27395

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PYH38_RS31930 Protein ID WP_280736330.1
Coordinates 585298..585720 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2A6LPC6
Locus tag PYH38_RS31925 Protein ID WP_010875326.1
Coordinates 585044..585301 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH38_RS31900 581479..581566 + 88 Protein_548 plasmid stability protein stbC -
PYH38_RS31905 (PYH38_006380) 581784..583343 - 1560 WP_280736325.1 E2 ligase fold family C protein -
PYH38_RS31910 (PYH38_006381) 583346..583786 - 441 WP_280736327.1 Mov34/MPN/PAD-1 family protein -
PYH38_RS31915 (PYH38_006382) 583831..584436 - 606 WP_280736328.1 hypothetical protein -
PYH38_RS31920 (PYH38_006383) 584429..584725 - 297 WP_280736329.1 DUF2604 domain-containing protein -
PYH38_RS31925 (PYH38_006384) 585044..585301 + 258 WP_010875326.1 plasmid stability protein stbC Antitoxin
PYH38_RS31930 (PYH38_006385) 585298..585720 + 423 WP_280736330.1 type II toxin-antitoxin system VapC family toxin Toxin
PYH38_RS31935 (PYH38_006386) 585938..587310 - 1373 Protein_555 ISNCY family transposase -
PYH38_RS31940 (PYH38_006387) 587426..587614 - 189 Protein_556 IS30 family transposase -
PYH38_RS31945 (PYH38_006388) 588039..588371 + 333 WP_280736331.1 hypothetical protein -
PYH38_RS31950 (PYH38_006389) 589704..590543 + 840 WP_280736332.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..629446 629446


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15121.44 Da        Isoelectric Point: 4.6812

>T274932 WP_280736330.1 NZ_CP120372:585298-585720 [Sinorhizobium numidicum]
MIVLDTNVISELWKAEPDRTVLAWIDAQMIETLYLSAITVAELRFGLAAMPAGKRRTIFQNRLEGEVLPALAGRVLPFDL
DASRSYADLMAQAKTSGKAIGKADGYIAATAVAHGFMVATRDTSPFEAAGLDIINPWEPA

Download         Length: 423 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9428.65 Da        Isoelectric Point: 6.0775

>AT274932 WP_010875326.1 NZ_CP120372:585044-585301 [Sinorhizobium numidicum]
MANVTVRNLPDEVHRALRVRAAMHGRSTEAEIRDILETTVRPPERVKLGSLLASIAHEAGGLTDAEAEHFNQLRDKTPAE
PMSFE

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2A6LPC6

References