Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 179295..179971 Replicon plasmid unnamed
Accession NZ_CP120369
Organism Sinorhizobium numidicum strain CIP 109850

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PYH37_RS29995 Protein ID WP_280736330.1
Coordinates 179295..179717 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2A6LPC6
Locus tag PYH37_RS30000 Protein ID WP_010875326.1
Coordinates 179714..179971 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYH37_RS29975 (PYH37_005995) 174472..175311 - 840 WP_280736332.1 response regulator transcription factor -
PYH37_RS29980 (PYH37_005996) 176644..176976 - 333 WP_280736331.1 hypothetical protein -
PYH37_RS29985 (PYH37_005997) 177401..177589 + 189 Protein_164 IS30 family transposase -
PYH37_RS29990 (PYH37_005998) 177705..179077 + 1373 Protein_165 ISNCY family transposase -
PYH37_RS29995 (PYH37_005999) 179295..179717 - 423 WP_280736330.1 type II toxin-antitoxin system VapC family toxin Toxin
PYH37_RS30000 (PYH37_006000) 179714..179971 - 258 WP_010875326.1 plasmid stability protein stbC Antitoxin
PYH37_RS30005 (PYH37_006001) 180290..180586 + 297 WP_280736329.1 DUF2604 domain-containing protein -
PYH37_RS30010 (PYH37_006002) 180579..181184 + 606 WP_280736328.1 hypothetical protein -
PYH37_RS30015 (PYH37_006003) 181229..181669 + 441 WP_280736327.1 Mov34/MPN/PAD-1 family protein -
PYH37_RS30020 (PYH37_006004) 181672..183231 + 1560 WP_280736325.1 E2 ligase fold family C protein -
PYH37_RS30025 183449..183536 - 88 Protein_172 plasmid stability protein stbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..629445 629445


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15121.44 Da        Isoelectric Point: 4.6812

>T274925 WP_280736330.1 NZ_CP120369:c179717-179295 [Sinorhizobium numidicum]
MIVLDTNVISELWKAEPDRTVLAWIDAQMIETLYLSAITVAELRFGLAAMPAGKRRTIFQNRLEGEVLPALAGRVLPFDL
DASRSYADLMAQAKTSGKAIGKADGYIAATAVAHGFMVATRDTSPFEAAGLDIINPWEPA

Download         Length: 423 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9428.65 Da        Isoelectric Point: 6.0775

>AT274925 WP_010875326.1 NZ_CP120369:c179971-179714 [Sinorhizobium numidicum]
MANVTVRNLPDEVHRALRVRAAMHGRSTEAEIRDILETTVRPPERVKLGSLLASIAHEAGGLTDAEAEHFNQLRDKTPAE
PMSFE

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2A6LPC6

References