Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 965995..966593 Replicon plasmid pSkuCCBAU71714a
Accession NZ_CP120366
Organism Sinorhizobium kummerowiae strain CCBAU 71714

Toxin (Protein)


Gene name relE Uniprot ID Q930F0
Locus tag PZL22_RS29195 Protein ID WP_010967243.1
Coordinates 966300..966593 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q930F1
Locus tag PZL22_RS29190 Protein ID WP_010967242.1
Coordinates 965995..966303 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZL22_RS29170 (PZL22_005837) 962025..962972 - 948 WP_127668391.1 substrate-binding domain-containing protein -
PZL22_RS29175 (PZL22_005838) 963047..963358 - 312 WP_127634532.1 MocE family 2Fe-2S type ferredoxin -
PZL22_RS29180 (PZL22_005839) 963355..964389 - 1035 WP_127701581.1 sterol desaturase family protein -
PZL22_RS29185 (PZL22_005840) 964569..965570 - 1002 WP_041170005.1 LacI family DNA-binding transcriptional regulator -
PZL22_RS29190 (PZL22_005841) 965995..966303 + 309 WP_010967242.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PZL22_RS29195 (PZL22_005842) 966300..966593 + 294 WP_010967243.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
PZL22_RS29200 (PZL22_005843) 966730..967676 + 947 WP_088895623.1 IS630-like element ISRm2011-2 family transposase -
PZL22_RS29205 (PZL22_005844) 967886..969220 - 1335 WP_284718729.1 ISNCY-like element ISRm17 family transposase -
PZL22_RS29210 (PZL22_005845) 969586..970785 - 1200 WP_028005114.1 NAD-dependent formate dehydrogenase -
PZL22_RS29215 (PZL22_005846) 971200..971265 + 66 Protein_969 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB / htpB 1..1418903 1418903


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-53)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11278.93 Da        Isoelectric Point: 6.4734

>T274920 WP_010967243.1 NZ_CP120366:966300-966593 [Sinorhizobium kummerowiae]
MRLVWARYALDDRDTIFSYIERENPRAAVHVDEEIVSAVRRLLDFPESGRPGRIAGTRELVIPRTPYIAAYMVMEDRIRI
LRVLHGAQKWPSELDDG

Download         Length: 294 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11210.58 Da        Isoelectric Point: 5.6604

>AT274920 WP_010967242.1 NZ_CP120366:965995-966303 [Sinorhizobium kummerowiae]
MASNALVQTRIDAEVKERATAVLENMGLTVSDAVRILLTRTANEGALPLELFSHSEAHDAWFRAKVLRALEDTRPDVDDA
DADAHFRERRAAALRKAAAGDR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q930F0

Antitoxin

Source ID Structure
AlphaFold DB Q930F1

References