Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 932358..932938 Replicon plasmid pSkuCCBAU71714a
Accession NZ_CP120366
Organism Sinorhizobium kummerowiae strain CCBAU 71714

Toxin (Protein)


Gene name vapC Uniprot ID Q92XP1
Locus tag PZL22_RS29025 Protein ID WP_010968151.1
Coordinates 932358..932741 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F7XCL0
Locus tag PZL22_RS29030 Protein ID WP_013851145.1
Coordinates 932738..932938 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZL22_RS29000 (PZL22_005802) 928407..929048 - 642 WP_234836496.1 DUF433 domain-containing protein -
PZL22_RS29005 (PZL22_005803) 929304..929651 - 348 WP_234708636.1 TIGR02588 family protein -
PZL22_RS29010 (PZL22_005804) 929747..930583 - 837 WP_127535252.1 TIGR02587 family membrane protein -
PZL22_RS29015 (PZL22_005805) 930916..931227 + 312 WP_164843122.1 hypothetical protein -
PZL22_RS29020 (PZL22_005806) 931514..931900 - 387 WP_234708651.1 response regulator -
PZL22_RS29025 (PZL22_005807) 932358..932741 - 384 WP_010968151.1 type II toxin-antitoxin system VapC family toxin Toxin
PZL22_RS29030 (PZL22_005808) 932738..932938 - 201 WP_013851145.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PZL22_RS29035 (PZL22_005809) 935188..936666 - 1479 WP_284718730.1 calcium-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB / htpB 1..1418903 1418903
- flank IS/Tn - - 927012..928346 1334


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14292.54 Da        Isoelectric Point: 6.9172

>T274919 WP_010968151.1 NZ_CP120366:c932741-932358 [Sinorhizobium kummerowiae]
VILADTSIWIDHFRHTDAELRRIIEDDRLLCHPAVIGELALGSLRERSSVIAFLMAQREALVATHQEVMMMIDRHAIFSM
GIGYTDAHLLASVLLDQRMALWTRDKRLQAAAEKAGASLHTPAHTRN

Download         Length: 384 bp

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7096.22 Da        Isoelectric Point: 11.1107

>AT274919 WP_013851145.1 NZ_CP120366:c932938-932738 [Sinorhizobium kummerowiae]
MRSTINLDDTLMERAKSLTGTKETAALVRQALETLVRVESGKRLIALGGTMPDAEAAPRRRSAAAK

Download         Length: 201 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92XP1

Antitoxin

Source ID Structure
AlphaFold DB A0A7W6MID2

References