Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 450095..450702 | Replicon | plasmid pSkuCCBAU71714a |
| Accession | NZ_CP120366 | ||
| Organism | Sinorhizobium kummerowiae strain CCBAU 71714 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | PZL22_RS26550 | Protein ID | WP_017264738.1 |
| Coordinates | 450095..450349 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | H0G1X1 |
| Locus tag | PZL22_RS26555 | Protein ID | WP_003530441.1 |
| Coordinates | 450346..450702 (+) | Length | 119 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PZL22_RS26520 (PZL22_005307) | 445496..446200 | - | 705 | WP_010968042.1 | haloacid dehalogenase type II | - |
| PZL22_RS26525 (PZL22_005308) | 446291..447163 | + | 873 | WP_010968043.1 | LysR family transcriptional regulator | - |
| PZL22_RS26530 (PZL22_005309) | 447214..447369 | - | 156 | WP_017264742.1 | hypothetical protein | - |
| PZL22_RS26535 (PZL22_005310) | 447455..447613 | - | 159 | WP_017276730.1 | hypothetical protein | - |
| PZL22_RS26540 (PZL22_005311) | 447737..448777 | - | 1041 | WP_010968044.1 | NAD(P)H-binding protein | - |
| PZL22_RS26545 (PZL22_005312) | 448866..449753 | + | 888 | WP_014528000.1 | LysR family transcriptional regulator | - |
| PZL22_RS26550 (PZL22_005313) | 450095..450349 | + | 255 | WP_017264738.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| PZL22_RS26555 (PZL22_005314) | 450346..450702 | + | 357 | WP_003530441.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| PZL22_RS26560 (PZL22_005315) | 451075..451731 | - | 657 | WP_010968046.1 | SGNH/GDSL hydrolase family protein | - |
| PZL22_RS26565 (PZL22_005316) | 451761..452711 | - | 951 | WP_010968047.1 | ABC transporter permease | - |
| PZL22_RS26570 (PZL22_005317) | 452714..453685 | - | 972 | WP_010968048.1 | ABC transporter permease | - |
| PZL22_RS26575 (PZL22_005318) | 453702..455195 | - | 1494 | WP_010968049.1 | sugar ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | htpB / htpB | 1..1418903 | 1418903 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9294.62 Da Isoelectric Point: 9.8124
>T274918 WP_017264738.1 NZ_CP120366:450095-450349 [Sinorhizobium kummerowiae]
MNSKQRKTLAAVFKDPASGTIEWAAIENLLVAAGADVIEGNGSRVKFEKDGIIASFHRPHPDKEAKRYQVRDAREFLMQI
GVTP
MNSKQRKTLAAVFKDPASGTIEWAAIENLLVAAGADVIEGNGSRVKFEKDGIIASFHRPHPDKEAKRYQVRDAREFLMQI
GVTP
Download Length: 255 bp
Antitoxin
Download Length: 119 a.a. Molecular weight: 13236.85 Da Isoelectric Point: 4.9920
>AT274918 WP_003530441.1 NZ_CP120366:450346-450702 [Sinorhizobium kummerowiae]
MNTMTYNGYHARIEFDAEDEVFFGKIAGISDVIGFHGDSVAELKKAFHEAVDDYLETCRKIGKEPQRPYSGKMMFRVAPE
VHRRAALAAELSGKSLNQWAEEVLEEAADHFAEARLSA
MNTMTYNGYHARIEFDAEDEVFFGKIAGISDVIGFHGDSVAELKKAFHEAVDDYLETCRKIGKEPQRPYSGKMMFRVAPE
VHRRAALAAELSGKSLNQWAEEVLEEAADHFAEARLSA
Download Length: 357 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|