274916

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3396..4081 Replicon plasmid pSkuCCBAU71714a
Accession NZ_CP120366
Organism Sinorhizobium kummerowiae strain CCBAU 71714

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PZL22_RS24375 Protein ID WP_088198215.1
Coordinates 3396..3815 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PZL22_RS24380 Protein ID WP_088196198.1
Coordinates 3812..4081 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZL22_RS24365 (PZL22_004877) 1..2172 + 2172 WP_127634375.1 molybdopterin-dependent oxidoreductase -
PZL22_RS24370 (PZL22_004878) 2909..3067 + 159 WP_164820653.1 hypothetical protein -
PZL22_RS24375 (PZL22_004879) 3396..3815 - 420 WP_088198215.1 type II toxin-antitoxin system VapC family toxin Toxin
PZL22_RS24380 (PZL22_004880) 3812..4081 - 270 WP_088196198.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PZL22_RS24385 (PZL22_004881) 4212..4678 + 467 Protein_4 LysR substrate-binding domain-containing protein -
PZL22_RS24390 (PZL22_004882) 4769..5644 - 876 WP_164820652.1 LysR family transcriptional regulator -
PZL22_RS24400 (PZL22_004884) 7162..7371 + 210 WP_234837684.1 hypothetical protein -
PZL22_RS24405 (PZL22_004885) 7428..7808 - 381 WP_127525420.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB / htpB 1..1418903 1418903


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(18-55)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14837.05 Da        Isoelectric Point: 4.5732

>T274916 WP_088198215.1 NZ_CP120366:c3815-3396 [Sinorhizobium kummerowiae]
VSRLYMLDTDIVSELARNPQGAVTKRIAEVGPDAICVSIITAAELRYGCAKKGSSKLLAQIETILESMQVLALDVPADAE
YGGIRAELEAAGRPIGPNDLFIAAHACMLGAVLVTANSSEFTRIRDLKVENWLDFTSSG

Download         Length: 420 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10202.68 Da        Isoelectric Point: 4.5716

>AT274916 WP_088196198.1 NZ_CP120366:c4081-3812 [Sinorhizobium kummerowiae]
MPQLRHNEPTPPREAKLFRNNRSQAVRIPADFELPGDRVMIHRDGDRLIIEPVLRKNLLEVLAGLEPLGSEDEFPDVDET
LLPVKEIDL

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References