Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3154765..3155405 Replicon chromosome
Accession NZ_CP120365
Organism Sinorhizobium kummerowiae strain CCBAU 71714

Toxin (Protein)


Gene name vapC Uniprot ID H0G6N1
Locus tag PZL22_RS22050 Protein ID WP_003533691.1
Coordinates 3154765..3155151 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID H0G6N0
Locus tag PZL22_RS22055 Protein ID WP_003533689.1
Coordinates 3155151..3155405 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZL22_RS22025 (PZL22_004409) 3150231..3150710 + 480 WP_003537307.1 GNAT family N-acetyltransferase -
PZL22_RS22030 (PZL22_004410) 3150753..3151202 - 450 WP_003537305.1 nucleoside deaminase -
PZL22_RS22035 (PZL22_004411) 3151277..3152998 + 1722 WP_127517016.1 pseudouridine synthase -
PZL22_RS22040 (PZL22_004412) 3153005..3153565 + 561 WP_003533694.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
PZL22_RS22045 (PZL22_004413) 3153638..3154537 + 900 WP_003533692.1 patatin-like phospholipase family protein -
PZL22_RS22050 (PZL22_004414) 3154765..3155151 - 387 WP_003533691.1 type II toxin-antitoxin system VapC family toxin Toxin
PZL22_RS22055 (PZL22_004415) 3155151..3155405 - 255 WP_003533689.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PZL22_RS22060 (PZL22_004416) 3155544..3157376 - 1833 WP_003533687.1 monovalent cation:proton antiporter-2 (CPA2) family protein -
PZL22_RS22065 (PZL22_004417) 3157528..3158874 + 1347 WP_284718564.1 TldD/PmbA family protein -
PZL22_RS22070 (PZL22_004418) 3158919..3159737 + 819 WP_003533685.1 3'(2'),5'-bisphosphate nucleotidase CysQ -
PZL22_RS22075 (PZL22_004419) 3159798..3160034 + 237 WP_003533684.1 DUF4170 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13904.77 Da        Isoelectric Point: 4.5716

>T274913 WP_003533691.1 NZ_CP120365:c3155151-3154765 [Sinorhizobium kummerowiae]
MVIDTSAIAAIAFNEQEAGSFREKIADDPVRLISAATALEAAMVIETRLGEAAGAELDLWLYKANVEIVAVTAEHMDQAR
RAWRRFGKGRHPAGLNFGDCFSYALAFLTNEPLLFKGSDFSQTDIPAA

Download         Length: 387 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9472.63 Da        Isoelectric Point: 4.8660

>AT274913 WP_003533689.1 NZ_CP120365:c3155405-3155151 [Sinorhizobium kummerowiae]
MALSIKDTETEQLARTLARRTGESITLATKRALEERLRRTDTAARRAALLEDLEAIQRRWNAMPVLDSRSSDDIIGYDED
GLPS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0G6N1

Antitoxin

Source ID Structure
AlphaFold DB H0G6N0

References