274912

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2790412..2790977 Replicon chromosome
Accession NZ_CP120365
Organism Sinorhizobium kummerowiae strain CCBAU 71714

Toxin (Protein)


Gene name brnT Uniprot ID H0G3P4
Locus tag PZL22_RS20320 Protein ID WP_003531565.1
Coordinates 2790732..2790977 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID H0G3P5
Locus tag PZL22_RS20315 Protein ID WP_003531566.1
Coordinates 2790412..2790735 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZL22_RS20295 (PZL22_004063) 2786275..2787075 + 801 WP_003531572.1 TVP38/TMEM64 family protein -
PZL22_RS20300 (PZL22_004064) 2787098..2788519 + 1422 WP_003531570.1 NAD(P)/FAD-dependent oxidoreductase -
PZL22_RS20305 (PZL22_004065) 2788594..2790114 + 1521 WP_003531568.1 HAMP domain-containing sensor histidine kinase -
PZL22_RS20315 (PZL22_004067) 2790412..2790735 - 324 WP_003531566.1 BrnA antitoxin family protein Antitoxin
PZL22_RS20320 (PZL22_004068) 2790732..2790977 - 246 WP_003531565.1 BrnT family toxin Toxin
PZL22_RS20325 (PZL22_004069) 2791412..2792125 + 714 WP_003531563.1 DNA helicase -
PZL22_RS20330 (PZL22_004070) 2792312..2793007 - 696 WP_015007123.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
PZL22_RS20335 (PZL22_004071) 2793199..2793687 + 489 WP_003531560.1 RidA family protein -
PZL22_RS20340 (PZL22_004072) 2793896..2794513 + 618 WP_003531558.1 hypothetical protein -
PZL22_RS20345 (PZL22_004073) 2794601..2795746 + 1146 WP_003531550.1 alpha-hydroxy acid oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-77)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-101)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 8990.48 Da        Isoelectric Point: 9.7323

>T274912 WP_003531565.1 NZ_CP120365:c2790977-2790732 [Sinorhizobium kummerowiae]
MKVTYDETKRQINIGKHGYDIAELDMEFFASSVVVPAKEGRFMAIGVLRNGVIAVVFARLGSEGISIISMRDASRKERSL
L

Download         Length: 246 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11933.51 Da        Isoelectric Point: 10.2830

>AT274912 WP_003531566.1 NZ_CP120365:c2790735-2790412 [Sinorhizobium kummerowiae]
MTSLSRRIRHISDKEEAAIQRKIASDPDAPEATDEQLAKAKPFAEAFPDLAESIKRARGRPAVENPRQQISIRLDPDVIE
HYKATGKGWQSRMNDDLRKAAGLKKAG

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0G3P4

Antitoxin

Source ID Structure
AlphaFold DB H0G3P5

References