Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2268573..2269234 Replicon chromosome
Accession NZ_CP120365
Organism Sinorhizobium kummerowiae strain CCBAU 71714

Toxin (Protein)


Gene name vapC Uniprot ID H0G400
Locus tag PZL22_RS17895 Protein ID WP_003531794.1
Coordinates 2268573..2268977 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID H0G3Z9
Locus tag PZL22_RS17900 Protein ID WP_003531793.1
Coordinates 2268974..2269234 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZL22_RS17880 (PZL22_003580) 2264145..2265257 + 1113 WP_003535893.1 3-isopropylmalate dehydrogenase -
PZL22_RS17885 (PZL22_003581) 2265386..2266093 + 708 WP_003535894.1 phosphatase PAP2 family protein -
PZL22_RS17890 (PZL22_003582) 2266194..2268083 - 1890 WP_003535895.1 MFS transporter -
PZL22_RS17895 (PZL22_003583) 2268573..2268977 - 405 WP_003531794.1 type II toxin-antitoxin system VapC family toxin Toxin
PZL22_RS17900 (PZL22_003584) 2268974..2269234 - 261 WP_003531793.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PZL22_RS17905 (PZL22_003585) 2269647..2270681 + 1035 WP_003531790.1 aspartate-semialdehyde dehydrogenase -
PZL22_RS17910 (PZL22_003586) 2270854..2271675 + 822 WP_003531785.1 lytic transglycosylase domain-containing protein -
PZL22_RS17915 (PZL22_003587) 2272022..2272705 - 684 WP_010970569.1 carbonic anhydrase -
PZL22_RS17920 (PZL22_003588) 2272879..2273760 - 882 WP_003531772.1 pyridoxal kinase PdxY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(8-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14480.69 Da        Isoelectric Point: 6.7257

>T274911 WP_003531794.1 NZ_CP120365:c2268977-2268573 [Sinorhizobium kummerowiae]
VISHILDTSAVIALIGRKSDALVTRVLHSPQGIIGLPSVVAYELYFGAQKSAKAQHNLETLRLLMADFPILDFDRNDAFV
AGEIRAALAAKGTPIGPYDVLIAGQAKARGLTLVTNNVGEFNRVENLRVEDWSL

Download         Length: 405 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9913.20 Da        Isoelectric Point: 5.1253

>AT274911 WP_003531793.1 NZ_CP120365:c2269234-2268974 [Sinorhizobium kummerowiae]
MPHLARVFQSGNSQAVRLPKEFRFNVDRVEITQEGDALILRPHVEQGEQWSSLKAALARGMSEDFMMCGREQPEQQDRPE
LDAVFR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0G400

Antitoxin

Source ID Structure
AlphaFold DB H0G3Z9

References