Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 1559935..1560701 Replicon chromosome
Accession NZ_CP120365
Organism Sinorhizobium kummerowiae strain CCBAU 71714

Toxin (Protein)


Gene name tacT Uniprot ID H0G6D3
Locus tag PZL22_RS14650 Protein ID WP_003533488.1
Coordinates 1560219..1560701 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID H0G6D4
Locus tag PZL22_RS14645 Protein ID WP_003533490.1
Coordinates 1559935..1560219 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZL22_RS14630 (PZL22_002930) 1555405..1556793 + 1389 WP_003533497.1 lipopolysaccharide biosynthesis protein -
PZL22_RS14635 (PZL22_002931) 1556797..1558068 + 1272 WP_003533495.1 GNAT family N-acetyltransferase -
PZL22_RS14640 (PZL22_002932) 1558084..1559730 - 1647 WP_003533493.1 AMP-binding protein -
PZL22_RS14645 (PZL22_002933) 1559935..1560219 + 285 WP_003533490.1 DUF1778 domain-containing protein Antitoxin
PZL22_RS14650 (PZL22_002934) 1560219..1560701 + 483 WP_003533488.1 GNAT family N-acetyltransferase Toxin
PZL22_RS14660 (PZL22_002936) 1561166..1561675 + 510 WP_003533487.1 disulfide bond formation protein B -
PZL22_RS14665 (PZL22_002937) 1561707..1562264 - 558 WP_003533486.1 HNH endonuclease -
PZL22_RS14670 (PZL22_002938) 1562370..1563017 - 648 WP_003533485.1 DNA-3-methyladenine glycosylase -
PZL22_RS14675 (PZL22_002939) 1563170..1564066 + 897 WP_003533484.1 tRNA glutamyl-Q(34) synthetase GluQRS -
PZL22_RS14680 (PZL22_002940) 1564085..1564960 - 876 WP_010970093.1 YihY/virulence factor BrkB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-142)

Antitoxin

Vibrio phage ICP1, Orf50

(1-92)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17463.88 Da        Isoelectric Point: 7.3827

>T274909 WP_003533488.1 NZ_CP120365:1560219-1560701 [Sinorhizobium kummerowiae]
MLSAPTPLGEAHDFDLFQSGNDTLDDWLRRRAHANQASGASRTYVIAEEWRVVGYYCLASGALDLADAPSSVRRNMPDPI
PMAVLGRLAIDRDWQGKGLGAALLQDAVLRSSQAADIMGIRGLLVHAISGEAKAFYEHYGFQCSPNHPMTLVLSLKGKRR

Download         Length: 483 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10771.12 Da        Isoelectric Point: 7.3175

>AT274909 WP_003533490.1 NZ_CP120365:1559935-1560219 [Sinorhizobium kummerowiae]
MATKSSTDTHAKPVNLRIREDIRKVIDRAASIRGKTRSDFMIDAAYRAAEDTLLDQTLVRVDEHSYRHYLDILDQPPSGD
GFERLMNAPKPWQS

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0G6D3

Antitoxin

Source ID Structure
AlphaFold DB H0G6D4

References