Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 1495965..1496897 Replicon plasmid pSkuCCBAU71714b
Accession NZ_CP120364
Organism Sinorhizobium kummerowiae strain CCBAU 71714

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PZL22_RS06855 Protein ID WP_284718348.1
Coordinates 1496343..1496897 (+) Length 185 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID H0G7T7
Locus tag PZL22_RS06850 Protein ID WP_003534594.1
Coordinates 1495965..1496336 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZL22_RS06830 (PZL22_001370) 1491852..1492235 + 384 WP_284718346.1 RidA family protein -
PZL22_RS06835 (PZL22_001371) 1492252..1494240 + 1989 WP_095919428.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -
PZL22_RS06840 (PZL22_001372) 1494237..1495106 + 870 WP_284718347.1 hydroxymethylglutaryl-CoA lyase -
PZL22_RS06845 (PZL22_001373) 1495103..1495888 + 786 WP_127517568.1 crotonase/enoyl-CoA hydratase family protein -
PZL22_RS06850 (PZL22_001374) 1495965..1496336 + 372 WP_003534594.1 DUF2384 domain-containing protein Antitoxin
PZL22_RS06855 (PZL22_001375) 1496343..1496897 + 555 WP_284718348.1 RES family NAD+ phosphorylase Toxin
PZL22_RS06860 (PZL22_001376) 1497035..1498405 - 1371 WP_284718349.1 FAD-binding oxidoreductase -
PZL22_RS06865 (PZL22_001377) 1498517..1499623 - 1107 WP_284718350.1 sulfate/molybdate ABC transporter ATP-binding protein -
PZL22_RS06870 (PZL22_001378) 1499639..1500514 - 876 WP_127517805.1 sulfate ABC transporter permease subunit CysW -
PZL22_RS06875 (PZL22_001379) 1500504..1501370 - 867 WP_010975580.1 sulfate ABC transporter permease subunit CysT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - htpB 1..1543136 1543136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(23-177)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20301.17 Da        Isoelectric Point: 6.7528

>T274905 WP_284718348.1 NZ_CP120364:1496343-1496897 [Sinorhizobium kummerowiae]
MGKHIPPASRPDPELTPSVERITLWRAFVPRWAHMPLSGAGAARFGGRWNPIGVPAIYGARELSTAWAEYNQGFVQHPAL
IVQLELRGAKLADLTDASVLLGLGVDEAIHRCEWRDALDKGAVPETHRLQSDLLARDYHGVIYPSFMSPGGTCVALWRWN
GPEEPRLDVIDPDGRLPKSPASWV

Download         Length: 555 bp

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13095.23 Da        Isoelectric Point: 9.9996

>AT274905 WP_003534594.1 NZ_CP120364:1495965-1496336 [Sinorhizobium kummerowiae]
IMAVDFQIPAARFGDDHSPFLSARLVADRLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA

Download         Length: 372 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB H0G7T7

References