Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1271398..1272065 Replicon plasmid pSkuCCBAU71714b
Accession NZ_CP120364
Organism Sinorhizobium kummerowiae strain CCBAU 71714

Toxin (Protein)


Gene name vapC Uniprot ID H0FTU2
Locus tag PZL22_RS05855 Protein ID WP_003525860.1
Coordinates 1271398..1271841 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92WE1
Locus tag PZL22_RS05860 Protein ID WP_010975287.1
Coordinates 1271838..1272065 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZL22_RS05835 (PZL22_001171) 1266855..1269047 + 2193 WP_127515813.1 hydantoinase B/oxoprolinase family protein -
PZL22_RS05840 (PZL22_001172) 1269051..1269548 + 498 WP_003525855.1 acetone carboxylase subunit gamma -
PZL22_RS05845 (PZL22_001173) 1269545..1270375 + 831 WP_284718264.1 SDR family oxidoreductase -
PZL22_RS05850 (PZL22_001174) 1270444..1271382 + 939 WP_284718493.1 choline ABC transporter substrate-binding protein -
PZL22_RS05855 (PZL22_001175) 1271398..1271841 - 444 WP_003525860.1 PIN domain-containing protein Toxin
PZL22_RS05860 (PZL22_001176) 1271838..1272065 - 228 WP_010975287.1 hypothetical protein Antitoxin
PZL22_RS05865 (PZL22_001177) 1272248..1272721 - 474 WP_003525863.1 DUF2269 family protein -
PZL22_RS05870 (PZL22_001178) 1272721..1274010 - 1290 WP_003525864.1 SDR family oxidoreductase -
PZL22_RS05875 (PZL22_001179) 1274380..1275672 + 1293 WP_014527485.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
PZL22_RS05880 (PZL22_001180) 1275789..1276670 + 882 WP_003525869.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - htpB 1..1543136 1543136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 15648.03 Da        Isoelectric Point: 7.4215

>T274904 WP_003525860.1 NZ_CP120364:c1271841-1271398 [Sinorhizobium kummerowiae]
VTFLLDVNVLIALIDPSHIGHDDAHEWFASIGQTAWATCPITENGVIRIVGNPKYPNSPGSPLPVMEIVAKLRSLPGHVF
WPDDVSLVGSSDIIPSKILTSGQVTDTYLLALAKVRGGKLATFDRKLSAAAVTKGNSALHLIATNRS

Download         Length: 444 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8174.39 Da        Isoelectric Point: 9.1096

>AT274904 WP_010975287.1 NZ_CP120364:c1272065-1271838 [Sinorhizobium kummerowiae]
MRTTLAIDDDVLIAAKAMATQQQRSVGEVISELARRSLRRPRSGGERNGIPLLSPRPDAPPVTLEIVNALRDELA

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0FTU2

Antitoxin

Source ID Structure
AlphaFold DB Q92WE1

References