Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 921078..921600 Replicon plasmid pSkuCCBAU71714b
Accession NZ_CP120364
Organism Sinorhizobium kummerowiae strain CCBAU 71714

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PZL22_RS04170 Protein ID WP_284718168.1
Coordinates 921316..921600 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID H0FXK0
Locus tag PZL22_RS04165 Protein ID WP_003527850.1
Coordinates 921078..921326 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZL22_RS04140 (PZL22_000831) 916549..917616 + 1068 WP_127613890.1 ABC transporter substrate-binding protein -
PZL22_RS04145 (PZL22_000832) 917613..918656 + 1044 WP_003527864.1 iron ABC transporter permease -
PZL22_RS04150 (PZL22_000833) 918653..919453 + 801 WP_003527862.1 ABC transporter ATP-binding protein -
PZL22_RS04155 (PZL22_000834) 919457..920251 + 795 WP_003527860.1 methyltransferase domain-containing protein -
PZL22_RS04160 (PZL22_000835) 920335..920460 - 126 Protein_830 IS481 family transposase -
PZL22_RS04165 (PZL22_000836) 921078..921326 + 249 WP_003527850.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
PZL22_RS04170 (PZL22_000837) 921316..921600 + 285 WP_284718168.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PZL22_RS04175 (PZL22_000838) 921691..921951 - 261 Protein_833 helix-turn-helix domain-containing protein -
PZL22_RS04180 (PZL22_000839) 922532..922930 + 399 WP_003527845.1 hypothetical protein -
PZL22_RS04185 (PZL22_000840) 923097..923282 + 186 WP_010974989.1 hypothetical protein -
PZL22_RS04190 (PZL22_000841) 923286..923732 - 447 WP_003527841.1 DNA-binding protein -
PZL22_RS04195 (PZL22_000842) 924021..924230 + 210 WP_003527838.1 dodecin family protein -
PZL22_RS04200 (PZL22_000843) 924765..926144 + 1380 WP_003527829.1 sodium:alanine symporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - htpB 1..1543136 1543136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-93)

Antitoxin

Antitoxin ParD

(3-78)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10885.48 Da        Isoelectric Point: 10.3083

>T274903 WP_284718168.1 NZ_CP120364:921316-921600 [Sinorhizobium kummerowiae]
MATELPFRLAPAAKADLRKIWRYTARRWSLEQAETYQDQLYTAFEGLAAGTKKGRNVDVRPGYLKYPAGSHIVYFRDRGD
RIDIIRILHGRMDA

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8888.73 Da        Isoelectric Point: 4.2176

>AT274903 WP_003527850.1 NZ_CP120364:921078-921326 [Sinorhizobium kummerowiae]
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB H0FXK0

References