Detailed information of TA system TA274894

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 4057259..4058665
• Replicon: chromosome
• Accession: NZ_CP120359
• Organism: Pseudomonas sp. AA-38

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: PVE35_RS18750
• Protein ID: WP_268178629.1
• Coordinates: 4058096..4058665 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: PVE35_RS18745
• Protein ID: WP_268178628.1
• Coordinates: 4057259..4058092 (-)
• Length: 278 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PVE35_RS18705	4052837..4053547	+	711	WP_277372655.1	dihydromonapterin reductase	-
PVE35_RS18710	4053571..4054131	+	561	WP_268178620.1	GTP cyclohydrolase I FolE	-
PVE35_RS18715	4054131..4054502	+	372	WP_268178622.1	dihydroneopterin triphosphate 2'-epimerase	-
PVE35_RS18720	4054582..4054875	+	294	WP_277372656.1	DUF1244 domain-containing protein	-
PVE35_RS18725	4054872..4055213	+	342	WP_277372657.1	HopJ type III effector protein	-
PVE35_RS18730	4055374..4055961	+	588	WP_268178625.1	putative glycolipid-binding domain-containing protein	-
PVE35_RS18735	4056161..4056490	-	330	WP_268178626.1	AzlD domain-containing protein	-
PVE35_RS18740	4056490..4057194	-	705	WP_268178627.1	AzlC family ABC transporter permease	-
PVE35_RS18745	4057259..4058092	-	834	WP_268178628.1	AraC family transcriptional regulator	Antitoxin
PVE35_RS18750	4058096..4058665	-	570	WP_268178629.1	GNAT family protein	Toxin
PVE35_RS18755	4058859..4062347	+	3489	WP_268178630.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (14-146)

Antitoxin

• DNA binding HTH domain, AraC-type (196-273)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21543.70 Da
• Isoelectric Point: 8.9244

>T274894 WP_268178629.1 NZ_CP120359:c4058665-4058096 [Pseudomonas sp. AA-38]
MFKPQLVTLQRGALRLEPLADNDIPALVALAEANREELLYMNGTLRLDWYRSALADQREQRALPFVIRLGDRLVGTTRFA
DFLNALPACEIGWTWLDREQHGSGLNTTIKYLMLKHAFDNWGMVRVQLKTAASNLRSQRAIEKLGAVREGLLRNHRRLAD
GRLDDTVLYSITDQEWPQVRQALEASFGA

Nucleotide

• Length: 570 bp

Antitoxin

Protein

• Length: 278 a.a.
• Molecular weight: 31392.88 Da
• Isoelectric Point: 9.3234

>AT274894 WP_268178628.1 NZ_CP120359:c4058092-4057259 [Pseudomonas sp. AA-38]
MQPDATREHVRFSTSADAQGVELLSARFIEHRFAPHVHDGHVIAVLEAGAERYRYRGIEHLAGAGCIALLNPDEVHTGSK
GAEQGWQYRVFYPQPGTFDTLLEELELRPSTPMFQDSVHHDPLLATRLSVLHRLLETPRSDALQRQTLWREVMLELLQRY
ARLPVPRAAGREPRVVAMAKELLASRLYEPPSLEMLAESVNLSPFHFARVFRRATGLPPHAWLKQRRLEQARALLRQGSA
PLSVAMQLGFADQSHLSRQFKQAYGIAPGEYRRACQT

Nucleotide

• Length: 834 bp