Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2768843..2769795 Replicon chromosome
Accession NZ_CP120356
Organism Rhodococcus rhodochrous strain LH-B3

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag PVE95_RS12725 Protein ID WP_277369634.1
Coordinates 2768843..2769412 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A0V9UHB2
Locus tag PVE95_RS12730 Protein ID WP_060653044.1
Coordinates 2769409..2769795 (-) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVE95_RS12715 2765711..2767072 + 1362 WP_277369632.1 cytochrome P450 -
PVE95_RS12720 2767079..2768809 + 1731 WP_277369633.1 CocE/NonD family hydrolase -
PVE95_RS12725 2768843..2769412 - 570 WP_277369634.1 zeta toxin family protein Toxin
PVE95_RS12730 2769409..2769795 - 387 WP_060653044.1 hypothetical protein Antitoxin
PVE95_RS12735 2770000..2771070 + 1071 WP_272267573.1 class I SAM-dependent methyltransferase -
PVE95_RS12740 2771140..2771505 + 366 WP_277369635.1 HNH endonuclease -
PVE95_RS12745 2772885..2773819 - 935 Protein_2501 TAXI family TRAP transporter solute-binding subunit -
PVE95_RS12750 2774120..2774514 - 395 Protein_2502 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-105)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 20524.65 Da        Isoelectric Point: 10.6895

>T274889 WP_277369634.1 NZ_CP120356:c2769412-2768843 [Rhodococcus rhodochrous]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIARQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEAGFTVVLHVMLVPEAMSVLRVQHRVASGGHAVPEDKIRARYRRLWPLVAEAIGRADQASVYDTASGTP
VVVARFAGGVPVGAVRWPGWTPAALTGLG

Download         Length: 570 bp

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 13920.31 Da        Isoelectric Point: 4.5912

>AT274889 WP_060653044.1 NZ_CP120356:c2769795-2769409 [Rhodococcus rhodochrous]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTRELSELTAAEGRLFDAEI
DARLADGLAHTDYAEVLAARGVTTVVLDDEGRLVEQGPDGSRRVLDDA

Download         Length: 387 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9UHB2

References