Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3478997..3479610 Replicon chromosome
Accession NZ_CP120353
Organism Parabacteroides distasonis strain F1-28 isolate human Intestinal

Toxin (Protein)


Gene name hicA Uniprot ID E1YXK9
Locus tag P2T59_RS14965 Protein ID WP_005866745.1
Coordinates 3478997..3479257 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E1YXL0
Locus tag P2T59_RS14970 Protein ID WP_005866743.1
Coordinates 3479269..3479610 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2T59_RS14950 (P2T59_14950) 3474688..3476094 - 1407 WP_005861168.1 di-heme oxidoredictase family protein -
P2T59_RS14955 (P2T59_14955) 3476112..3477323 - 1212 WP_008780678.1 imelysin family protein -
P2T59_RS14960 (P2T59_14960) 3477354..3478667 - 1314 WP_005861166.1 porin -
P2T59_RS14965 (P2T59_14965) 3478997..3479257 + 261 WP_005866745.1 type II toxin-antitoxin system HicA family toxin Toxin
P2T59_RS14970 (P2T59_14970) 3479269..3479610 + 342 WP_005866743.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P2T59_RS14975 (P2T59_14975) 3479944..3480597 - 654 WP_122144444.1 transcriptional regulator -
P2T59_RS14980 (P2T59_14980) 3480607..3480876 - 270 WP_005866739.1 hypothetical protein -
P2T59_RS14985 (P2T59_14985) 3481826..3481981 - 156 Protein_2932 AAA family ATPase -
P2T59_RS14990 (P2T59_14990) 3482358..3483905 + 1548 WP_122144446.1 arylsulfatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-79)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10036.60 Da        Isoelectric Point: 10.0271

>T274888 WP_005866745.1 NZ_CP120353:3478997-3479257 [Parabacteroides distasonis]
MGSKEKLIERFCKLPKDFTYEETLKLLSSYGYNEHNKGATSGSRVRFKNEQTGQYIDIHKPHPGSIMKEWMMKAIYQHLK
SNGLIK

Download         Length: 261 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12391.06 Da        Isoelectric Point: 4.8780

>AT274888 WP_005866743.1 NZ_CP120353:3479269-3479610 [Parabacteroides distasonis]
MDYLEYKGYKGSVEYSKADNCLCGKVLGMSKDLILYEGNTIDELRADFEAGVESYLAGCLADGVEPRKPYSGTLNIRISP
EIHSRIAALAQEAGTTINGYIKQALENQLKLAH

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A496DRY4

Antitoxin

Source ID Structure
AlphaFold DB A0A069SEG1

References