Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 854714..855374 Replicon chromosome
Accession NZ_CP120347
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_2_2021

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag P1828_RS04160 Protein ID WP_000244756.1
Coordinates 854961..855374 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag P1828_RS04155 Protein ID WP_000351186.1
Coordinates 854714..854980 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1828_RS04135 (850642) 850642..852075 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
P1828_RS04140 (852234) 852234..852545 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
P1828_RS04145 (852709) 852709..853368 + 660 WP_000250289.1 hemolysin III family protein -
P1828_RS04150 (853484) 853484..854464 - 981 WP_000874175.1 tRNA-modifying protein YgfZ -
P1828_RS04155 (854714) 854714..854980 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
P1828_RS04160 (854961) 854961..855374 + 414 WP_000244756.1 protein YgfX Toxin
P1828_RS04165 (855427) 855427..855948 - 522 WP_001055885.1 flavodoxin FldB -
P1828_RS04170 (856061) 856061..856957 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
P1828_RS04175 (856981) 856981..857694 + 714 WP_000745622.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P1828_RS04180 (857700) 857700..859433 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T274852 WP_000244756.1 NZ_CP120347:854961-855374 [Salmonella enterica subsp. enterica serovar Muenchen]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT274852 WP_000351186.1 NZ_CP120347:854714-854980 [Salmonella enterica subsp. enterica serovar Muenchen]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References