Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3521661..3522281 | Replicon | chromosome |
Accession | NZ_CP120345 | ||
Organism | Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_3_2021 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | V1H8E6 |
Locus tag | P1706_RS17500 | Protein ID | WP_001280991.1 |
Coordinates | 3522063..3522281 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | V1H4V6 |
Locus tag | P1706_RS17495 | Protein ID | WP_000344807.1 |
Coordinates | 3521661..3522035 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P1706_RS17485 (3516800) | 3516800..3517993 | + | 1194 | WP_001039202.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
P1706_RS17490 (3518016) | 3518016..3521165 | + | 3150 | WP_001132508.1 | efflux RND transporter permease AcrB | - |
P1706_RS17495 (3521661) | 3521661..3522035 | + | 375 | WP_000344807.1 | Hha toxicity modulator TomB | Antitoxin |
P1706_RS17500 (3522063) | 3522063..3522281 | + | 219 | WP_001280991.1 | HHA domain-containing protein | Toxin |
P1706_RS17505 (3522460) | 3522460..3523011 | + | 552 | WP_001278792.1 | maltose O-acetyltransferase | - |
P1706_RS17510 (3523128) | 3523128..3523598 | + | 471 | WP_000136181.1 | YlaC family protein | - |
P1706_RS17515 (3523654) | 3523654..3523794 | - | 141 | WP_001197749.1 | type B 50S ribosomal protein L36 | - |
P1706_RS17520 (3523800) | 3523800..3524060 | - | 261 | WP_000801415.1 | type B 50S ribosomal protein L31 | - |
P1706_RS17525 (3524285) | 3524285..3525835 | + | 1551 | WP_000213140.1 | EAL domain-containing protein | - |
P1706_RS17535 (3526066) | 3526066..3526455 | + | 390 | WP_000961285.1 | MGMT family protein | - |
P1706_RS17540 (3526488) | 3526488..3527057 | - | 570 | WP_020437370.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8613.97 Da Isoelectric Point: 8.9008
>T274840 WP_001280991.1 NZ_CP120345:3522063-3522281 [Salmonella enterica subsp. enterica serovar Muenchen]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
Antitoxin
Download Length: 125 a.a. Molecular weight: 14453.27 Da Isoelectric Point: 5.1444
>AT274840 WP_000344807.1 NZ_CP120345:3521661-3522035 [Salmonella enterica subsp. enterica serovar Muenchen]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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