Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3521663..3522283 Replicon chromosome
Accession NZ_CP120343
Organism Salmonella enterica subsp. enterica serovar Paratyphi B strain PS_Mu_4_2021

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P1708_RS17510 Protein ID WP_001280991.1
Coordinates 3522065..3522283 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P1708_RS17505 Protein ID WP_000344807.1
Coordinates 3521663..3522037 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1708_RS17495 (3516802) 3516802..3517995 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1708_RS17500 (3518018) 3518018..3521167 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P1708_RS17505 (3521663) 3521663..3522037 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P1708_RS17510 (3522065) 3522065..3522283 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P1708_RS17515 (3522462) 3522462..3523013 + 552 WP_001278792.1 maltose O-acetyltransferase -
P1708_RS17520 (3523130) 3523130..3523600 + 471 WP_000136181.1 YlaC family protein -
P1708_RS17525 (3523656) 3523656..3523796 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P1708_RS17530 (3523802) 3523802..3524062 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P1708_RS17535 (3524287) 3524287..3525837 + 1551 WP_000213140.1 EAL domain-containing protein -
P1708_RS17545 (3526068) 3526068..3526457 + 390 WP_000961285.1 MGMT family protein -
P1708_RS17550 (3526490) 3526490..3527059 - 570 WP_020437370.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T274822 WP_001280991.1 NZ_CP120343:3522065-3522283 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT274822 WP_000344807.1 NZ_CP120343:3521663-3522037 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References