Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1017312..1018126 Replicon chromosome
Accession NZ_CP120343
Organism Salmonella enterica subsp. enterica serovar Paratyphi B strain PS_Mu_4_2021

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag P1708_RS04905 Protein ID WP_000971655.1
Coordinates 1017312..1017839 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P1708_RS04910 Protein ID WP_000855694.1
Coordinates 1017836..1018126 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1708_RS04875 (1013612) 1013612..1014009 + 398 Protein_955 cytoplasmic protein -
P1708_RS04880 (1014200) 1014200..1014439 + 240 Protein_956 hypothetical protein -
P1708_RS04885 (1014596) 1014596..1015264 + 669 WP_000445914.1 hypothetical protein -
P1708_RS04890 (1015291) 1015291..1015785 + 495 WP_000424942.1 hypothetical protein -
P1708_RS04895 (1016030) 1016030..1016686 - 657 WP_020437799.1 protein-serine/threonine phosphatase -
P1708_RS04900 (1017024) 1017024..1017239 + 216 Protein_960 IS5/IS1182 family transposase -
P1708_RS04905 (1017312) 1017312..1017839 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
P1708_RS04910 (1017836) 1017836..1018126 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P1708_RS04915 (1018396) 1018396..1018596 - 201 Protein_963 transposase -
P1708_RS04920 (1018837) 1018837..1019163 + 327 WP_000393302.1 hypothetical protein -
P1708_RS04925 (1019436) 1019436..1019783 - 348 WP_001669174.1 DUF1493 family protein -
P1708_RS04930 (1019768) 1019768..1020217 - 450 WP_021294302.1 hypothetical protein -
P1708_RS04935 (1020649) 1020649..1021092 - 444 WP_001522905.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P1708_RS04940 (1021548) 1021548..1022198 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1017099..1017239 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T274817 WP_000971655.1 NZ_CP120343:c1017839-1017312 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT274817 WP_000855694.1 NZ_CP120343:c1018126-1017836 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References