Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4082895..4083411 Replicon chromosome
Accession NZ_CP120341
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_PB_1_2021

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag P1831_RS19695 Protein ID WP_000220578.1
Coordinates 4082895..4083179 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag P1831_RS19700 Protein ID WP_000212724.1
Coordinates 4083169..4083411 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1831_RS19680 (4078107) 4078107..4079759 + 1653 WP_000155045.1 alpha,alpha-phosphotrehalase -
P1831_RS19685 (4080168) 4080168..4082306 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P1831_RS19690 (4082427) 4082427..4082891 + 465 WP_053445439.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P1831_RS19695 (4082895) 4082895..4083179 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P1831_RS19700 (4083169) 4083169..4083411 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P1831_RS19705 (4083489) 4083489..4085402 - 1914 WP_053445438.1 BglG family transcription antiterminator -
P1831_RS19710 (4085419) 4085419..4086159 - 741 WP_053445437.1 KDGP aldolase family protein -
P1831_RS19715 (4086156) 4086156..4087274 - 1119 WP_001139178.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P1831_RS19720 (4087258) 4087258..4088391 - 1134 WP_053445436.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T274812 WP_000220578.1 NZ_CP120341:c4083179-4082895 [Salmonella enterica subsp. enterica serovar Muenchen]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT274812 WP_000212724.1 NZ_CP120341:c4083411-4083169 [Salmonella enterica subsp. enterica serovar Muenchen]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References