Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3388004..3388624 Replicon chromosome
Accession NZ_CP120341
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_PB_1_2021

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P1831_RS16505 Protein ID WP_001280991.1
Coordinates 3388406..3388624 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P1831_RS16500 Protein ID WP_000344807.1
Coordinates 3388004..3388378 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1831_RS16490 (3383143) 3383143..3384336 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1831_RS16495 (3384359) 3384359..3387508 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P1831_RS16500 (3388004) 3388004..3388378 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P1831_RS16505 (3388406) 3388406..3388624 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P1831_RS16510 (3388803) 3388803..3389354 + 552 WP_053444946.1 maltose O-acetyltransferase -
P1831_RS16515 (3389471) 3389471..3389941 + 471 WP_000136181.1 YlaC family protein -
P1831_RS16520 (3389997) 3389997..3390137 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P1831_RS16525 (3390143) 3390143..3390355 - 213 WP_283903176.1 50S ribosomal protein L31 -
P1831_RS16530 (3390529) 3390529..3392064 + 1536 WP_023181050.1 IS21 family transposase -
P1831_RS16535 (3392081) 3392081..3392836 + 756 WP_001282653.1 IS21-like element ISSso4 family helper ATPase IstB -
P1831_RS16540 (3392930) 3392930..3393049 - 120 Protein_3235 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T274811 WP_001280991.1 NZ_CP120341:3388406-3388624 [Salmonella enterica subsp. enterica serovar Muenchen]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT274811 WP_000344807.1 NZ_CP120341:3388004-3388378 [Salmonella enterica subsp. enterica serovar Muenchen]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References