Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 989966..990780 | Replicon | chromosome |
| Accession | NZ_CP120341 | ||
| Organism | Salmonella enterica subsp. enterica serovar Muenchen strain PS_PB_1_2021 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A3Y0CWF0 |
| Locus tag | P1831_RS04740 | Protein ID | WP_053444849.1 |
| Coordinates | 989966..990493 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | P1831_RS04745 | Protein ID | WP_000855694.1 |
| Coordinates | 990490..990780 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P1831_RS04720 (985269) | 985269..987836 | - | 2568 | WP_001005807.1 | DNA mismatch repair protein MutS | - |
| P1831_RS04725 (987995) | 987995..988515 | + | 521 | Protein_925 | cytoplasmic protein | - |
| P1831_RS04730 (988685) | 988685..989341 | - | 657 | WP_053444848.1 | protein-serine/threonine phosphatase | - |
| P1831_RS04735 (989691) | 989691..989893 | + | 203 | Protein_927 | IS5/IS1182 family transposase | - |
| P1831_RS04740 (989966) | 989966..990493 | - | 528 | WP_053444849.1 | GNAT family N-acetyltransferase | Toxin |
| P1831_RS04745 (990490) | 990490..990780 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| P1831_RS04750 (991050) | 991050..991250 | - | 201 | Protein_930 | transposase | - |
| P1831_RS04755 (991491) | 991491..991817 | + | 327 | WP_000393302.1 | hypothetical protein | - |
| P1831_RS04760 (992090) | 992090..992437 | - | 348 | WP_001669174.1 | DUF1493 family protein | - |
| P1831_RS04765 (992422) | 992422..992871 | - | 450 | WP_000381612.1 | membrane protein | - |
| P1831_RS04770 (993304) | 993304..993747 | - | 444 | WP_000715099.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| P1831_RS04775 (994205) | 994205..994855 | + | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 989717..989893 | 176 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19027.81 Da Isoelectric Point: 9.6420
>T274805 WP_053444849.1 NZ_CP120341:c990493-989966 [Salmonella enterica subsp. enterica serovar Muenchen]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSVQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVSLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSVQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVSLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT274805 WP_000855694.1 NZ_CP120341:c990780-990490 [Salmonella enterica subsp. enterica serovar Muenchen]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3Y0CWF0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |