Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 835845..836470 Replicon chromosome
Accession NZ_CP120341
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_PB_1_2021

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P1831_RS04065 Protein ID WP_000911337.1
Coordinates 836072..836470 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag P1831_RS04060 Protein ID WP_000557549.1
Coordinates 835845..836072 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1831_RS04030 (830908) 830908..832006 + 1099 WP_010989230.1 peptide chain release factor 2 -
P1831_RS04035 (832016) 832016..833533 + 1518 WP_000003339.1 lysine--tRNA ligase -
P1831_RS04040 (833609) 833609..834154 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
P1831_RS04045 (834419) 834419..835177 + 759 WP_000244328.1 amidase activator ActS -
P1831_RS04055 (835423) 835423..835636 - 214 Protein_793 hypothetical protein -
P1831_RS04060 (835845) 835845..836072 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
P1831_RS04065 (836072) 836072..836470 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
P1831_RS04070 (837275) 837275..837811 + 537 WP_053444818.1 STM3031 family outer membrane protein -
P1831_RS04075 (837850) 837850..838482 + 633 WP_023232674.1 YfdX family protein -
P1831_RS04080 (838802) 838802..839557 - 756 WP_001282653.1 IS21-like element ISSso4 family helper ATPase IstB -
P1831_RS04085 (839574) 839574..841109 - 1536 WP_023181050.1 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T274804 WP_000911337.1 NZ_CP120341:836072-836470 [Salmonella enterica subsp. enterica serovar Muenchen]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT274804 WP_000557549.1 NZ_CP120341:835845-836072 [Salmonella enterica subsp. enterica serovar Muenchen]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References