Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 826084..826744 Replicon chromosome
Accession NZ_CP120341
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_PB_1_2021

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag P1831_RS04005 Protein ID WP_000244756.1
Coordinates 826331..826744 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag P1831_RS04000 Protein ID WP_000351186.1
Coordinates 826084..826350 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1831_RS03980 (822013) 822013..823446 - 1434 WP_053444816.1 6-phospho-beta-glucosidase BglA -
P1831_RS03985 (823604) 823604..823915 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
P1831_RS03990 (824079) 824079..824738 + 660 WP_053444817.1 hemolysin III family protein -
P1831_RS03995 (824854) 824854..825834 - 981 WP_023260866.1 tRNA-modifying protein YgfZ -
P1831_RS04000 (826084) 826084..826350 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
P1831_RS04005 (826331) 826331..826744 + 414 WP_000244756.1 protein YgfX Toxin
P1831_RS04010 (826797) 826797..827318 - 522 WP_001055885.1 flavodoxin FldB -
P1831_RS04015 (827431) 827431..828327 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
P1831_RS04020 (828351) 828351..829064 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P1831_RS04025 (829070) 829070..830803 + 1734 WP_017465473.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T274803 WP_000244756.1 NZ_CP120341:826331-826744 [Salmonella enterica subsp. enterica serovar Muenchen]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT274803 WP_000351186.1 NZ_CP120341:826084-826350 [Salmonella enterica subsp. enterica serovar Muenchen]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References