Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 205843..206603 | Replicon | chromosome |
| Accession | NZ_CP120341 | ||
| Organism | Salmonella enterica subsp. enterica serovar Muenchen strain PS_PB_1_2021 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q57IH1 |
| Locus tag | P1831_RS00975 | Protein ID | WP_000533909.1 |
| Coordinates | 206118..206603 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | M7RHS4 |
| Locus tag | P1831_RS00970 | Protein ID | WP_000965886.1 |
| Coordinates | 205843..206130 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P1831_RS00950 (201248) | 201248..202159 | + | 912 | WP_001168551.1 | glycine--tRNA ligase subunit alpha | - |
| P1831_RS00955 (202169) | 202169..204238 | + | 2070 | WP_020437730.1 | glycine--tRNA ligase subunit beta | - |
| P1831_RS00960 (204628) | 204628..205056 | + | 429 | Protein_190 | IS3 family transposase | - |
| P1831_RS00965 (205198) | 205198..205665 | + | 468 | WP_000702452.1 | GNAT family N-acetyltransferase | - |
| P1831_RS00970 (205843) | 205843..206130 | + | 288 | WP_000965886.1 | DUF1778 domain-containing protein | Antitoxin |
| P1831_RS00975 (206118) | 206118..206603 | + | 486 | WP_000533909.1 | GNAT family N-acetyltransferase | Toxin |
| P1831_RS00980 (206974) | 206974..207513 | - | 540 | WP_000047139.1 | copper-binding periplasmic metallochaperone CueP | - |
| P1831_RS00985 (207687) | 207687..207899 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| P1831_RS00990 (208187) | 208187..208477 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| P1831_RS00995 (208916) | 208916..209626 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| P1831_RS01000 (209676) | 209676..210650 | - | 975 | WP_053445130.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| P1831_RS01005 (210869) | 210869..211531 | - | 663 | WP_053445131.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T274802 WP_000533909.1 NZ_CP120341:206118-206603 [Salmonella enterica subsp. enterica serovar Muenchen]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10950.60 Da Isoelectric Point: 4.6811
>AT274802 WP_000965886.1 NZ_CP120341:205843-206130 [Salmonella enterica subsp. enterica serovar Muenchen]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7F36 | |
| PDB | 7AK8 | |
| PDB | 5FVJ |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V2JDX2 |