Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3521685..3522305 Replicon chromosome
Accession NZ_CP120339
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_5_2021

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P1826_RS17525 Protein ID WP_001280991.1
Coordinates 3522087..3522305 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P1826_RS17520 Protein ID WP_000344807.1
Coordinates 3521685..3522059 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1826_RS17510 (3516824) 3516824..3518017 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1826_RS17515 (3518040) 3518040..3521189 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P1826_RS17520 (3521685) 3521685..3522059 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P1826_RS17525 (3522087) 3522087..3522305 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P1826_RS17530 (3522484) 3522484..3523035 + 552 WP_001278792.1 maltose O-acetyltransferase -
P1826_RS17535 (3523152) 3523152..3523622 + 471 WP_000136181.1 YlaC family protein -
P1826_RS17540 (3523678) 3523678..3523818 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P1826_RS17545 (3523824) 3523824..3524084 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P1826_RS17550 (3524309) 3524309..3525859 + 1551 WP_000213140.1 EAL domain-containing protein -
P1826_RS17560 (3526090) 3526090..3526479 + 390 WP_000961285.1 MGMT family protein -
P1826_RS17565 (3526512) 3526512..3527081 - 570 WP_020437370.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T274792 WP_001280991.1 NZ_CP120339:3522087-3522305 [Salmonella enterica subsp. enterica serovar Muenchen]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT274792 WP_000344807.1 NZ_CP120339:3521685-3522059 [Salmonella enterica subsp. enterica serovar Muenchen]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References