Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 854717..855377 Replicon chromosome
Accession NZ_CP120339
Organism Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_5_2021

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag P1826_RS04160 Protein ID WP_000244756.1
Coordinates 854964..855377 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag P1826_RS04155 Protein ID WP_000351186.1
Coordinates 854717..854983 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1826_RS04135 (850645) 850645..852078 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
P1826_RS04140 (852237) 852237..852548 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
P1826_RS04145 (852712) 852712..853371 + 660 WP_000250289.1 hemolysin III family protein -
P1826_RS04150 (853487) 853487..854467 - 981 WP_000874175.1 tRNA-modifying protein YgfZ -
P1826_RS04155 (854717) 854717..854983 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
P1826_RS04160 (854964) 854964..855377 + 414 WP_000244756.1 protein YgfX Toxin
P1826_RS04165 (855430) 855430..855951 - 522 WP_001055885.1 flavodoxin FldB -
P1826_RS04170 (856064) 856064..856960 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
P1826_RS04175 (856984) 856984..857697 + 714 WP_000745622.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P1826_RS04180 (857703) 857703..859436 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T274786 WP_000244756.1 NZ_CP120339:854964-855377 [Salmonella enterica subsp. enterica serovar Muenchen]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT274786 WP_000351186.1 NZ_CP120339:854717-854983 [Salmonella enterica subsp. enterica serovar Muenchen]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References