Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 48631..49274 | Replicon | plasmid pESI |
Accession | NZ_CP120338 | ||
Organism | Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_6_2021 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | A0A5T8FJ24 |
Locus tag | P1833_RS24090 | Protein ID | WP_023994137.1 |
Coordinates | 48631..49047 (-) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | A0A5T3Q059 |
Locus tag | P1833_RS24095 | Protein ID | WP_023994136.1 |
Coordinates | 49044..49274 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P1833_RS24060 (P1833_24060) | 44111..44902 | + | 792 | WP_023994142.1 | F4 (K88) fimbria minor subunit FaeH | - |
P1833_RS24065 (P1833_24065) | 44930..45694 | + | 765 | WP_023994141.1 | minor fimbrial protein | - |
P1833_RS24070 (P1833_24070) | 45897..46487 | + | 591 | WP_023994140.1 | hypothetical protein | - |
P1833_RS24075 (P1833_24075) | 46553..46765 | + | 213 | WP_023994139.1 | FaeA/PapI family transcriptional regulator | - |
P1833_RS24080 (P1833_24080) | 47026..47187 | + | 162 | WP_001816720.1 | hypothetical protein | - |
P1833_RS24085 (P1833_24085) | 47213..48061 | + | 849 | WP_023994138.1 | SdiA-regulated domain-containing protein | - |
P1833_RS24090 (P1833_24090) | 48631..49047 | - | 417 | WP_023994137.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
P1833_RS24095 (P1833_24095) | 49044..49274 | - | 231 | WP_023994136.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
P1833_RS24100 (P1833_24100) | 49898..50116 | + | 219 | WP_023994135.1 | type II toxin-antitoxin system antitoxin CcdA | - |
P1833_RS24105 (P1833_24105) | 50118..50423 | + | 306 | WP_023994134.1 | type II toxin-antitoxin system toxin CcdB | - |
P1833_RS24110 (P1833_24110) | 50425..50715 | + | 291 | WP_023994133.1 | hypothetical protein | - |
P1833_RS24115 (P1833_24115) | 50712..50987 | + | 276 | Protein_59 | 3'-5' exonuclease | - |
P1833_RS24120 (P1833_24120) | 51058..51174 | + | 117 | Protein_60 | hypothetical protein | - |
P1833_RS24125 (P1833_24125) | 51164..51879 | - | 716 | Protein_61 | transposase | - |
P1833_RS24130 (P1833_24130) | 53161..53697 | + | 537 | WP_023994130.1 | fimbrial protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | ant(3'')-Ia / qacE / sul1 / tet(A) / dfrA14 | faeC / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS | 1..285085 | 285085 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15123.58 Da Isoelectric Point: 8.5291
>T274783 WP_023994137.1 NZ_CP120338:c49047-48631 [Salmonella enterica subsp. enterica serovar Muenchen]
VKKMYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVNATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWGR
VKKMYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVNATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWGR
Download Length: 417 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5T8FJ24 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5T3Q059 |